2ivd

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[[Image:2ivd.jpg|left|200px]]
[[Image:2ivd.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ivd |SIZE=350|CAPTION= <scene name='initialview01'>2ivd</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2ivd", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Twn+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACJ:5-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-2-NITROBENZOIC+ACID'>ACJ</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TWN:(3S)-3-[(2S,3S,4R)-3,4-DIMETHYLTETRAHYDROFURAN-2-YL]BUTYL+LAURATE'>TWN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protoporphyrinogen_oxidase Protoporphyrinogen oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.4 1.3.3.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2ivd| PDB=2ivd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ivd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ivd OCA], [http://www.ebi.ac.uk/pdbsum/2ivd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ivd RCSB]</span>
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}}
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'''STRUCTURE OF PROTOPORPHYRINOGEN OXIDASE FROM MYXOCOCCUS XANTHUS WITH ACIFLUORFEN'''
'''STRUCTURE OF PROTOPORPHYRINOGEN OXIDASE FROM MYXOCOCCUS XANTHUS WITH ACIFLUORFEN'''
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[[Category: Mohan, C G.]]
[[Category: Mohan, C G.]]
[[Category: Sturrock, E D.]]
[[Category: Sturrock, E D.]]
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[[Category: acifluorfen]]
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[[Category: Acifluorfen]]
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[[Category: chlorophyll biosynthesis]]
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[[Category: Chlorophyll biosynthesis]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: haem biosynthesis]]
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[[Category: Haem biosynthesis]]
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[[Category: heme biosynthesis]]
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[[Category: Heme biosynthesis]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: porphyria]]
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[[Category: Porphyria]]
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[[Category: porphyrin biosynthesis]]
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[[Category: Porphyrin biosynthesis]]
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[[Category: protoporphyrinogen oxidase]]
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[[Category: Protoporphyrinogen oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:55:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:10 2008''
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Revision as of 04:55, 4 May 2008

Image:2ivd.jpg

Template:STRUCTURE 2ivd

STRUCTURE OF PROTOPORPHYRINOGEN OXIDASE FROM MYXOCOCCUS XANTHUS WITH ACIFLUORFEN


Overview

Protoporphyrinogen IX oxidase, a monotopic membrane protein, which catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX in the heme/chlorophyll biosynthetic pathway, is distributed widely throughout nature. Here we present the structure of protoporphyrinogen IX oxidase from Myxococcus xanthus, an enzyme with similar catalytic properties to human protoporphyrinogen IX oxidase that also binds the common plant herbicide, acifluorfen. In the native structure, the planar porphyrinogen substrate is mimicked by a Tween 20 molecule, tracing three sides of the macrocycle. In contrast, acifluorfen does not mimic the planarity of the substrate but is accommodated by the shape of the binding pocket and held in place by electrostatic and aromatic interactions. A hydrophobic patch surrounded by positively charged residues suggests the position of the membrane anchor, differing from the one proposed for the tobacco mitochondrial protoporphyrinogen oxidase. Interestingly, there is a discrepancy between the dimerization state of the protein in solution and in the crystal. Conserved structural features are discussed in relation to a number of South African variegate porphyria-causing mutations in the human enzyme.

About this Structure

2IVD is a Single protein structure of sequence from Myxococcus xanthus. Full crystallographic information is available from OCA.

Reference

Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen., Corradi HR, Corrigall AV, Boix E, Mohan CG, Sturrock ED, Meissner PN, Acharya KR, J Biol Chem. 2006 Dec 15;281(50):38625-33. Epub 2006 Oct 17. PMID:17046834 Page seeded by OCA on Sun May 4 07:55:56 2008

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