2ivf

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[[Image:2ivf.jpg|left|200px]]
[[Image:2ivf.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ivf |SIZE=350|CAPTION= <scene name='initialview01'>2ivf</scene>, resolution 1.88&Aring;
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The line below this paragraph, containing "STRUCTURE_2ivf", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Md1+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MD1:PHOSPHORIC+ACID+4-(2-AMINO-4-OXO-3,4,5,6,-TETRAHYDRO-PTERIDIN-6-YL)-2-HYDROXY-3,4-DIMERCAPTO-BUT-3-EN-YL+ESTER+GUANYLATE+ESTER'>MD1</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ethylbenzene_hydroxylase Ethylbenzene hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.99.2 1.17.99.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2ivf| PDB=2ivf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ivf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ivf OCA], [http://www.ebi.ac.uk/pdbsum/2ivf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ivf RCSB]</span>
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}}
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'''ETHYLBENZENE DEHYDROGENASE FROM AROMATOLEUM AROMATICUM'''
'''ETHYLBENZENE DEHYDROGENASE FROM AROMATOLEUM AROMATICUM'''
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[[Category: Kloer, D P.]]
[[Category: Kloer, D P.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: anaerobic hydrocarbon degradation]]
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[[Category: Anaerobic hydrocarbon degradation]]
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[[Category: dmso reductase family]]
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[[Category: Dmso reductase family]]
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[[Category: fe/s cluster]]
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[[Category: Fe/s cluster]]
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[[Category: mo-bismgd enzyme]]
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[[Category: Mo-bismgd enzyme]]
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[[Category: moco]]
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[[Category: Moco]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:56:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:10 2008''
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Revision as of 04:56, 4 May 2008

Image:2ivf.jpg

Template:STRUCTURE 2ivf

ETHYLBENZENE DEHYDROGENASE FROM AROMATOLEUM AROMATICUM


Overview

Anaerobic degradation of hydrocarbons was discovered a decade ago, and ethylbenzene dehydrogenase was one of the first characterized enzymes involved. The structure of the soluble periplasmic 165 kDa enzyme was established at 1.88 A resolution. It is a heterotrimer. The alpha subunit contains the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, one with an open pyran ring, and an iron-sulfur cluster with a histidine ligand. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration. The beta subunit contains four iron-sulfur clusters and is structurally related to ferredoxins. The gamma subunit is the first known protein with a methionine and a lysine as axial heme ligands. The catalytic product was modeled into the active center, showing the reaction geometry. A mechanism consistent with activity and inhibition data of ethylbenzene-related compounds is proposed.

About this Structure

2IVF is a Protein complex structure of sequences from Azoarcus sp. eb1. Full crystallographic information is available from OCA.

Reference

Crystal structure of ethylbenzene dehydrogenase from Aromatoleum aromaticum., Kloer DP, Hagel C, Heider J, Schulz GE, Structure. 2006 Sep;14(9):1377-88. PMID:16962969 Page seeded by OCA on Sun May 4 07:56:07 2008

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