2ivn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ivn.jpg|left|200px]]
[[Image:2ivn.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ivn |SIZE=350|CAPTION= <scene name='initialview01'>2ivn</scene>, resolution 1.65&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ivn", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Anp+Binding+Site+For+Chain+A'>AC2</scene> and <scene name='pdbsite=AC3:Mg+Binding+Site+For+Chain+A'>AC3</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/O-sialoglycoprotein_endopeptidase O-sialoglycoprotein endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.57 3.4.24.57] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ivn| PDB=2ivn | SCENE= }}
-
|RELATEDENTRY=[[2ivo|2IVO]], [[2ivp|2IVP]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ivn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ivn OCA], [http://www.ebi.ac.uk/pdbsum/2ivn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ivn RCSB]</span>
+
-
}}
+
'''STRUCTURE OF UP1 PROTEIN'''
'''STRUCTURE OF UP1 PROTEIN'''
Line 34: Line 31:
[[Category: Tilbeurgh, H Van.]]
[[Category: Tilbeurgh, H Van.]]
[[Category: Ulryck, N.]]
[[Category: Ulryck, N.]]
-
[[Category: fe/zn dependent nucleotide phosphatase]]
+
[[Category: Fe/zn dependent nucleotide phosphatase]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: hypothetical protein]]
+
[[Category: Hypothetical protein]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: metalloprotease]]
+
[[Category: Metalloprotease]]
-
[[Category: protease]]
+
[[Category: Protease]]
-
[[Category: up1 keops complex]]
+
[[Category: Up1 keops complex]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:56:44 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:15 2008''
+

Revision as of 04:56, 4 May 2008

Image:2ivn.jpg

Template:STRUCTURE 2ivn

STRUCTURE OF UP1 PROTEIN


Overview

The Kae1 (Kinase-associated endopeptidase 1) protein is a member of the recently identified transcription complex EKC and telomeres maintenance complex KEOPS in yeast. Kae1 homologues are encoded by all sequenced genomes in the three domains of life. Although annotated as putative endopeptidases, the actual functions of these universal proteins are unknown. Here we show that the purified Kae1 protein (Pa-Kae1) from Pyrococcus abyssi is an iron-protein with a novel type of ATP-binding site. Surprisingly, this protein did not exhibit endopeptidase activity in vitro but binds cooperatively to single and double-stranded DNA and induces unusual DNA conformational change. Furthermore, Pa-Kae1 exhibits a class I apurinic (AP)-endonuclease activity (AP-lyase). Both DNA binding and AP-endonuclease activity are inhibited by ATP. Kae1 is thus a novel and atypical universal DNA interacting protein whose importance could rival those of RecA (RadA/Rad51) in the maintenance of genome integrity in all living cells.

About this Structure

2IVN is a Single protein structure of sequence from Pyrococcus abyssi. Full crystallographic information is available from OCA.

Reference

An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro., Hecker A, Leulliot N, Gadelle D, Graille M, Justome A, Dorlet P, Brochier C, Quevillon-Cheruel S, Le Cam E, van Tilbeurgh H, Forterre P, Nucleic Acids Res. 2007;35(18):6042-51. Epub 2007 Aug 30. PMID:17766251 Page seeded by OCA on Sun May 4 07:56:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ivn"
Personal tools