2ixr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ixr.jpg|left|200px]]
[[Image:2ixr.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ixr |SIZE=350|CAPTION= <scene name='initialview01'>2ixr</scene>, resolution 2.6&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ixr", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ixr| PDB=2ixr | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixr OCA], [http://www.ebi.ac.uk/pdbsum/2ixr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ixr RCSB]</span>
+
-
}}
+
'''BIPD OF BURKHOLDERIA PSEUDOMALLEI'''
'''BIPD OF BURKHOLDERIA PSEUDOMALLEI'''
Line 31: Line 28:
[[Category: Lea, S M.]]
[[Category: Lea, S M.]]
[[Category: Roversi, P.]]
[[Category: Roversi, P.]]
-
[[Category: bipd]]
+
[[Category: Bipd]]
-
[[Category: burkholderia pseudomallei]]
+
[[Category: Burkholderia pseudomallei]]
-
[[Category: t3ss]]
+
[[Category: T3ss]]
-
[[Category: toxin]]
+
[[Category: Toxin]]
-
[[Category: ttss]]
+
[[Category: Ttss]]
-
[[Category: type 3 secretion system]]
+
[[Category: Type 3 secretion system]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:03:02 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:50:12 2008''
+

Revision as of 05:03, 4 May 2008

Image:2ixr.jpg

Template:STRUCTURE 2ixr

BIPD OF BURKHOLDERIA PSEUDOMALLEI


Overview

Bacteria expressing type III secretion systems (T3SS) have been responsible for the deaths of millions worldwide, acting as key virulence elements in diseases ranging from plague to typhoid fever. The T3SS is composed of a basal body, which traverses both bacterial membranes, and an external needle through which effector proteins are secreted. We report multiple crystal structures of two proteins that sit at the tip of the needle and are essential for virulence: IpaD from Shigella flexneri and BipD from Burkholderia pseudomallei. The structures reveal that the N-terminal domains of the molecules are intramolecular chaperones that prevent premature oligomerization, as well as sharing structural homology with proteins involved in eukaryotic actin rearrangement. Crystal packing has allowed us to construct a model for the tip complex that is supported by mutations designed using the structure.

About this Structure

2IXR is a Single protein structure of sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.

Reference

Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD., Johnson S, Roversi P, Espina M, Olive A, Deane JE, Birket S, Field T, Picking WD, Blocker AJ, Galyov EE, Picking WL, Lea SM, J Biol Chem. 2007 Feb 9;282(6):4035-44. Epub 2006 Oct 31. PMID:17077085 Page seeded by OCA on Sun May 4 08:03:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ixr"
Personal tools