2iy9

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[[Image:2iy9.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy9 OCA], [http://www.ebi.ac.uk/pdbsum/2iy9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iy9 RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI'''
'''CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI'''
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Revision as of 05:04, 4 May 2008

Image:2iy9.gif

Template:STRUCTURE 2iy9

CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI


Overview

AB5 toxins are produced by pathogenic bacteria and consist of enzymatic A subunits that corrupt essential eukaryotic cell functions, and pentameric B subunits that mediate uptake into the target cell. AB5 toxins include the Shiga, cholera and pertussis toxins and a recently discovered fourth family, subtilase cytotoxin, which is produced by certain Shiga toxigenic strains of Escherichia coli. Here we show that the extreme cytotoxicity of this toxin for eukaryotic cells is due to a specific single-site cleavage of the essential endoplasmic reticulum chaperone BiP/GRP78. The A subunit is a subtilase-like serine protease; structural studies revealed an unusually deep active-site cleft, which accounts for its exquisite substrate specificity. A single amino-acid substitution in the BiP target site prevented cleavage, and co-expression of this resistant protein protected transfected cells against the toxin. BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death.

About this Structure

2IY9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP., Paton AW, Beddoe T, Thorpe CM, Whisstock JC, Wilce MC, Rossjohn J, Talbot UM, Paton JC, Nature. 2006 Oct 5;443(7111):548-52. PMID:17024087 Page seeded by OCA on Sun May 4 08:04:21 2008

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