2j37

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[[Image:2j37.gif|left|200px]]
[[Image:2j37.gif|left|200px]]
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{{Structure
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|PDB= 2j37 |SIZE=350|CAPTION= <scene name='initialview01'>2j37</scene>, resolution 8.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2j37", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_2j37| PDB=2j37 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j37 OCA], [http://www.ebi.ac.uk/pdbsum/2j37 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j37 RCSB]</span>
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'''MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS'''
'''MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS'''
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[[Category: Sinning, I.]]
[[Category: Sinning, I.]]
[[Category: Wild, K.]]
[[Category: Wild, K.]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: srp]]
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[[Category: Srp]]
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[[Category: translation/rna]]
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[[Category: Translation/rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:16:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:15 2008''
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Revision as of 05:16, 4 May 2008

Image:2j37.gif

Template:STRUCTURE 2j37

MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS


Overview

Membrane and secretory proteins can be co-translationally inserted into or translocated across the membrane. This process is dependent on signal sequence recognition on the ribosome by the signal recognition particle (SRP), which results in targeting of the ribosome-nascent-chain complex to the protein-conducting channel at the membrane. Here we present an ensemble of structures at subnanometre resolution, revealing the signal sequence both at the ribosomal tunnel exit and in the bacterial and eukaryotic ribosome-SRP complexes. Molecular details of signal sequence interaction in both prokaryotic and eukaryotic complexes were obtained by fitting high-resolution molecular models. The signal sequence is presented at the ribosomal tunnel exit in an exposed position ready for accommodation in the hydrophobic groove of the rearranged SRP54 M domain. Upon ribosome binding, the SRP54 NG domain also undergoes a conformational rearrangement, priming it for the subsequent docking reaction with the NG domain of the SRP receptor. These findings provide the structural basis for improving our understanding of the early steps of co-translational protein sorting.

About this Structure

2J37 is a Protein complex structure of sequences from Canis lupus familiaris, Canis sp., Haloarcula marismortui, Homo sapiens and Triticum aestivum. Full crystallographic information is available from OCA.

Reference

Following the signal sequence from ribosomal tunnel exit to signal recognition particle., Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R, Nature. 2006 Nov 23;444(7118):507-11. Epub 2006 Oct 29. PMID:17086193 Page seeded by OCA on Sun May 4 08:16:22 2008

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