2j3r
From Proteopedia
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'''THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.''' | '''THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.''' | ||
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[[Category: Kim, Y G.]] | [[Category: Kim, Y G.]] | ||
[[Category: Oh, B H.]] | [[Category: Oh, B H.]] | ||
| - | [[Category: | + | [[Category: Endoplasmic reticulum]] |
| - | [[Category: | + | [[Category: Er-golgi transport]] |
| - | [[Category: | + | [[Category: Golgi apparatus]] |
| - | [[Category: | + | [[Category: Lipoprotein]] |
| - | [[Category: | + | [[Category: Multisubunit tethering factor]] |
| - | [[Category: | + | [[Category: Palmitate]] |
| - | [[Category: | + | [[Category: Transport]] |
| - | [[Category: | + | [[Category: Trapp]] |
| - | [[Category: | + | [[Category: Vesicle transport]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:17:25 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:17, 4 May 2008
THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.
Overview
Transport protein particle (TRAPP) I is a multisubunit vesicle tethering factor composed of seven subunits involved in ER-to-Golgi trafficking. The functional mechanism of the complex and how the subunits interact to form a functional unit are unknown. Here, we have used a multidisciplinary approach that includes X-ray crystallography, electron microscopy, biochemistry, and yeast genetics to elucidate the architecture of TRAPP I. The complex is organized through lateral juxtaposition of the subunits into a flat and elongated particle. We have also localized the site of guanine nucleotide exchange activity to a highly conserved surface encompassing several subunits. We propose that TRAPP I attaches to Golgi membranes with its large flat surface containing many highly conserved residues and forms a platform for protein-protein interactions. This study provides the most comprehensive view of a multisubunit vesicle tethering complex to date, based on which a model for the function of this complex, involving Rab1-GTP and long, coiled-coil tethers, is presented.
About this Structure
2J3R is a Protein complex structure of sequences from Danio rerio and Mus musculus. Full crystallographic information is available from OCA.
Reference
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering., Kim YG, Raunser S, Munger C, Wagner J, Song YL, Cygler M, Walz T, Oh BH, Sacher M, Cell. 2006 Nov 17;127(4):817-30. PMID:17110339 Page seeded by OCA on Sun May 4 08:17:25 2008
