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2j4a

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[[Image:2j4a.jpg|left|200px]]
[[Image:2j4a.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2j4a |SIZE=350|CAPTION= <scene name='initialview01'>2j4a</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2j4a", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Oef+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=OEF:3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC+ACID'>OEF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2j4a| PDB=2j4a | SCENE= }}
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|RELATEDENTRY=[[1bsx|1BSX]], [[1n46|1N46]], [[1nax|1NAX]], [[1nq0|1NQ0]], [[1nq1|1NQ1]], [[1nq2|1NQ2]], [[1nuo|1NUO]], [[1q4x|1Q4X]], [[1r6g|1R6G]], [[1xzx|1XZX]], [[1y0x|1Y0X]], [[2h6w|2H6W]], [[2nll|2NLL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4a OCA], [http://www.ebi.ac.uk/pdbsum/2j4a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j4a RCSB]</span>
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}}
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'''HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084'''
'''HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Farnegardh, M.]]
[[Category: Farnegardh, M.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: deafness]]
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[[Category: Deafness]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: ligand binding domain]]
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[[Category: Ligand binding domain]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: nuclear receptor]]
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[[Category: Nuclear receptor]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: zinc]]
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[[Category: Zinc]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:18:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:44 2008''
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Revision as of 05:18, 4 May 2008

Image:2j4a.jpg

Template:STRUCTURE 2j4a

HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084


Overview

A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

About this Structure

2J4A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor., Koehler K, Gordon S, Brandt P, Carlsson B, Backsbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Farnegardh M, Rehnmark S, Malm J, J Med Chem. 2006 Nov 16;49(23):6635-7. PMID:17154490 Page seeded by OCA on Sun May 4 08:18:39 2008

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OCA

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