2j4d
From Proteopedia
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'''CRYPTOCHROME 3 FROM ARABIDOPSIS THALIANA''' | '''CRYPTOCHROME 3 FROM ARABIDOPSIS THALIANA''' | ||
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[[Category: Klar, T.]] | [[Category: Klar, T.]] | ||
[[Category: Pokorny, R.]] | [[Category: Pokorny, R.]] | ||
| - | [[Category: | + | [[Category: Blue-light response]] |
| - | [[Category: | + | [[Category: Chloroplast]] |
| - | [[Category: | + | [[Category: Chromophore]] |
| - | [[Category: | + | [[Category: Cryptochrome]] |
| - | [[Category: | + | [[Category: Dna-binding protein]] |
| - | [[Category: | + | [[Category: Fad]] |
| - | [[Category: | + | [[Category: Flavoprotein]] |
| - | [[Category: | + | [[Category: Mitochondrion]] |
| - | [[Category: | + | [[Category: Plastid]] |
| - | [[Category: | + | [[Category: Transit peptide]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:18:51 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:18, 4 May 2008
CRYPTOCHROME 3 FROM ARABIDOPSIS THALIANA
Overview
Cryptochromes are almost ubiquitous blue-light receptors and act in several species as central components of the circadian clock. Despite being evolutionary and structurally related with DNA photolyases, a class of light-driven DNA-repair enzymes, and having similar cofactor compositions, cryptochromes lack DNA-repair activity. Cryptochrome 3 from the plant Arabidopsis thaliana belongs to the DASH-type subfamily. Its crystal structure determined at 1.9 Angstroms resolution shows cryptochrome 3 in a dimeric state with the antenna cofactor 5,10-methenyltetrahydrofolate (MTHF) bound in a distance of 15.2 Angstroms to the U-shaped FAD chromophore. Spectroscopic studies on a mutant where a residue crucial for MTHF-binding, E149, was replaced by site-directed mutagenesis demonstrate that MTHF acts in cryptochrome 3 as a functional antenna for the photoreduction of FAD.
About this Structure
2J4D is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.
Reference
Cryptochrome 3 from Arabidopsis thaliana: structural and functional analysis of its complex with a folate light antenna., Klar T, Pokorny R, Moldt J, Batschauer A, Essen LO, J Mol Biol. 2007 Feb 23;366(3):954-64. Epub 2006 Dec 2. PMID:17188299 Page seeded by OCA on Sun May 4 08:18:51 2008
