2j5m

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[[Image:2j5m.jpg|left|200px]]
[[Image:2j5m.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2j5m |SIZE=350|CAPTION= <scene name='initialview01'>2j5m</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_2j5m", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Act+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2j5m| PDB=2j5m | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5m OCA], [http://www.ebi.ac.uk/pdbsum/2j5m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j5m RCSB]</span>
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}}
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'''STRUCTURE OF CHLOROPEROXIDASE COMPOUND 0'''
'''STRUCTURE OF CHLOROPEROXIDASE COMPOUND 0'''
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[[Category: Shaik, S.]]
[[Category: Shaik, S.]]
[[Category: Terner, J.]]
[[Category: Terner, J.]]
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[[Category: chloride]]
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[[Category: Chloride]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: iron]]
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[[Category: Iron]]
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[[Category: manganese]]
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[[Category: Manganese]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: peroxidase]]
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[[Category: Peroxidase]]
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[[Category: pyrrolidone carboxylic acid]]
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[[Category: Pyrrolidone carboxylic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:22:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:53:15 2008''
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Revision as of 05:22, 4 May 2008

Image:2j5m.jpg

Template:STRUCTURE 2j5m

STRUCTURE OF CHLOROPEROXIDASE COMPOUND 0


Overview

We have determined the crystal structure of the chloroperoxidase (CPO) hydroperoxo reaction intermediate (CPO compound 0) at 1.75-A resolution. The intermediate was generated through controlled photoreduction of the CPO oxygen complex during x-ray data collection, which was monitored by recording of the crystal absorption spectra. Initially, the peroxo-anion species was formed and then protonated to yield compound 0. Quantum chemical calculations indicate that the peroxo-anion species is not stable and collapses instantaneously to compound 0. Compound 0 is present in the ferric low-spin doublet ground state and is characterized by a long O O bond length of 1.5 A and a Fe O bond distance of 1.8 A, which is also observed in the crystal structure.

About this Structure

2J5M is a Single protein structure of sequence from Leptoxyphium fumago. Full crystallographic information is available from OCA.

Reference

Structure and quantum chemical characterization of chloroperoxidase compound 0, a common reaction intermediate of diverse heme enzymes., Kuhnel K, Derat E, Terner J, Shaik S, Schlichting I, Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):99-104. Epub 2006 Dec 26. PMID:17190816 Page seeded by OCA on Sun May 4 08:22:33 2008

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OCA

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