This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2z3q
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="2z3q" size="450" color="white" frame="true" align="right" spinBox="true" caption="2z3q, resolution 1.85Å" /> '''Crystal structure o...)
Next diff →
Revision as of 21:40, 12 November 2007
|
Crystal structure of the IL-15/IL-15Ra complex
Overview
Interleukin 15 (IL-15) and IL-2, which promote the survival of memory, CD8(+) T cells and regulatory T cells, respectively, bind receptor, complexes that share beta- and gamma-signaling subunits. Receptor, specificity is provided by unique, nonsignaling alpha-subunits. Whereas, IL-2 receptor-alpha (IL-2Ralpha) is expressed together in cis with the, beta- and gamma-subunits on T cells and B cells, IL-15Ralpha is expressed, in trans on antigen-presenting cells. Here we present a 1.85-A crystal, structure of the human IL-15-IL-15Ralpha complex. The structure provides, insight into the molecular basis of the specificity of cytokine, recognition and emphasizes the importance of water in generating this very, high-affinity complex. Despite very low IL-15-IL-2 sequence homology and, distinct receptor architecture, the topologies of the IL-15-IL-15Ralpha, and IL-2-IL-2Ralpha complexes are very similar. Our data raise the, possibility that IL-2, like IL-15, might be capable of being presented in, trans in the context of its unique receptor alpha-chain.
About this Structure
2Z3Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans., Chirifu M, Hayashi C, Nakamura T, Toma S, Shuto T, Kai H, Yamagata Y, Davis SJ, Ikemizu S, Nat Immunol. 2007 Sep;8(9):1001-7. Epub 2007 Jul 22. PMID:17643103
Page seeded by OCA on Mon Nov 12 23:46:39 2007
