2j6j

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[[Image:2j6j.jpg|left|200px]]
[[Image:2j6j.jpg|left|200px]]
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{{Structure
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|PDB= 2j6j |SIZE=350|CAPTION= <scene name='initialview01'>2j6j</scene>, resolution 3.000&Aring;
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The line below this paragraph, containing "STRUCTURE_2j6j", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Yb+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>
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{{STRUCTURE_2j6j| PDB=2j6j | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6j OCA], [http://www.ebi.ac.uk/pdbsum/2j6j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j6j RCSB]</span>
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'''PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN'''
'''PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN'''
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[[Category: Rey, F A.]]
[[Category: Rey, F A.]]
[[Category: Roche, S.]]
[[Category: Roche, S.]]
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[[Category: envelope protein]]
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[[Category: Envelope protein]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: transmembrane fusion]]
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[[Category: Transmembrane fusion]]
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[[Category: viral protein]]
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[[Category: Viral protein]]
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[[Category: virion protein]]
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[[Category: Virion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:25:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:53:41 2008''
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Revision as of 05:25, 4 May 2008

Image:2j6j.jpg

Template:STRUCTURE 2j6j

PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN


Overview

Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion via a low pH-induced structural rearrangement. Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change. In the prefusion form, G has the shape of a tripod with the fusion loops exposed, which point toward the viral membrane, and with the antigenic sites located at the distal end of the molecule. A large number of G glycoproteins, perhaps organized as in the crystals, act cooperatively to induce membrane merging.

About this Structure

2J6J is a Single protein structure of sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA.

Reference

Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G., Roche S, Rey FA, Gaudin Y, Bressanelli S, Science. 2007 Feb 9;315(5813):843-8. PMID:17289996 Page seeded by OCA on Sun May 4 08:25:08 2008

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