2j6k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2j6k.jpg|left|200px]]
[[Image:2j6k.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2j6k |SIZE=350|CAPTION= <scene name='initialview01'>2j6k</scene>, resolution 2.775&Aring;
+
The line below this paragraph, containing "STRUCTURE_2j6k", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2j6k| PDB=2j6k | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6k OCA], [http://www.ebi.ac.uk/pdbsum/2j6k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j6k RCSB]</span>
+
-
}}
+
'''N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)'''
'''N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)'''
Line 31: Line 28:
[[Category: Moncalian, G.]]
[[Category: Moncalian, G.]]
[[Category: Spinola-Amilibia, M.]]
[[Category: Spinola-Amilibia, M.]]
-
[[Category: adaptor protein]]
+
[[Category: Adaptor protein]]
-
[[Category: cd2 associated protein]]
+
[[Category: Cd2 associated protein]]
-
[[Category: coiled coil]]
+
[[Category: Coiled coil]]
-
[[Category: cytoskeletal rearrangement]]
+
[[Category: Cytoskeletal rearrangement]]
-
[[Category: egfr downregulation]]
+
[[Category: Egfr downregulation]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: protein binding]]
+
[[Category: Protein binding]]
-
[[Category: sh3]]
+
[[Category: Sh3]]
-
[[Category: sh3 domain]]
+
[[Category: Sh3 domain]]
-
[[Category: sh3-binding]]
+
[[Category: Sh3-binding]]
-
[[Category: signaling protein]]
+
[[Category: Signaling protein]]
-
[[Category: surface active protein]]
+
[[Category: Surface active protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:25:10 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:53:43 2008''
+

Revision as of 05:25, 4 May 2008

Image:2j6k.jpg

Template:STRUCTURE 2j6k

N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)


Overview

The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic adaptor proteins has the ability to engage multiple effectors and couple cargo trafficking with the cytoskeleton. CIN85 and CMS (Cas ligand with multiple Src homology 3 (SH3) domains) facilitate the formation of large multiprotein complexes required for an efficient internalization of cell surface receptors. It has recently been shown that c-Cbl/Cbl-b could mediate the formation of a ternary complex between one c-Cbl/Cbl-b molecule and two SH3 domains of CIN85, important for the ability of Cbl to promote epidermal growth factor receptor down-regulation. To further investigate whether multimerization is conserved within the family of adaptor proteins, we have solved the crystal structures of the CMS N-terminal SH3 domain-forming complexes with Cbl-b- and CD2-derived peptides. Together with biochemical evidence, the structures support the notion that, despite clear differences in the interaction surface, both Cbl-b and CD2 can mediate multimerization of N-terminal CMS SH3 domains. Detailed analyses on the interacting surfaces also provide the basis for a differential Cbl-b molecular recognition of CMS and CIN85.

About this Structure

2J6K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880 Page seeded by OCA on Sun May 4 08:25:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j6k"
Personal tools