2j6v

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[[Image:2j6v.gif|left|200px]]
[[Image:2j6v.gif|left|200px]]
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{{Structure
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|PDB= 2j6v |SIZE=350|CAPTION= <scene name='initialview01'>2j6v</scene>, resolution 1.55&Aring;
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The line below this paragraph, containing "STRUCTURE_2j6v", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mn+Binding+Site+For+Chain+B'>AC3</scene> and <scene name='pdbsite=AC4:Po4+Binding+Site+For+Chain+B'>AC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2j6v| PDB=2j6v | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6v OCA], [http://www.ebi.ac.uk/pdbsum/2j6v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j6v RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME UV DAMAGE ENDONUC'''
'''CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME UV DAMAGE ENDONUC'''
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[[Category: Paspaleva, K.]]
[[Category: Paspaleva, K.]]
[[Category: Thomassen, E A.J.]]
[[Category: Thomassen, E A.J.]]
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[[Category: dna binding protein]]
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[[Category: Dna binding protein]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: endonuclease]]
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[[Category: Endonuclease]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: plasmid]]
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[[Category: Plasmid]]
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[[Category: tim barrel]]
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[[Category: Tim barrel]]
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[[Category: uvde]]
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[[Category: Uvde]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:26:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:53:48 2008''
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Revision as of 05:26, 4 May 2008

Image:2j6v.gif

Template:STRUCTURE 2j6v

CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME UV DAMAGE ENDONUC


Overview

The ultraviolet damage endonuclease (UVDE) performs the initial step in an alternative excision repair pathway of UV-induced DNA damage, nicking immediately adjacent to the 5' phosphate of the damaged nucleotides. Unique for a single-protein DNA repair endonuclease, it can detect different types of damage. Here we show that Thermus thermophilus UVDE shares some essential structural features with Endo IV, an enzyme from the base excision repair pathway that exclusively nicks at abasic sites. A comparison between the structures indicates how DNA is bound by UVDE, how UVDE may recognize damage, and which of its residues are involved in catalysis. Furthermore, the comparison suggests an elegant explanation of UVDE's potential to recognize different types of damage. Incision assays including point mutants of UVDE confirmed the relevance of these conclusions.

About this Structure

2J6V is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the DNA repair enzyme ultraviolet damage endonuclease., Paspaleva K, Thomassen E, Pannu NS, Iwai S, Moolenaar GF, Goosen N, Abrahams JP, Structure. 2007 Oct;15(10):1316-24. PMID:17937920 Page seeded by OCA on Sun May 4 08:26:02 2008

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