2j6x

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[[Image:2j6x.jpg|left|200px]]
[[Image:2j6x.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2j6x |SIZE=350|CAPTION= <scene name='initialview01'>2j6x</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2j6x", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Fmn+Binding+Site+For+Chain+H'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2j6x| PDB=2j6x | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6x OCA], [http://www.ebi.ac.uk/pdbsum/2j6x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j6x RCSB]</span>
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}}
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'''THE CRYSTAL STRUCTURE OF LACTATE OXIDASE'''
'''THE CRYSTAL STRUCTURE OF LACTATE OXIDASE'''
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[[Category: Repo, H.]]
[[Category: Repo, H.]]
[[Category: Wang, E.]]
[[Category: Wang, E.]]
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[[Category: biosensor]]
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[[Category: Biosensor]]
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[[Category: flavoenzyme]]
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[[Category: Flavoenzyme]]
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[[Category: fmn-dependent]]
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[[Category: Fmn-dependent]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:26:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:53:53 2008''
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Revision as of 05:26, 4 May 2008

Image:2j6x.jpg

Template:STRUCTURE 2j6x

THE CRYSTAL STRUCTURE OF LACTATE OXIDASE


Overview

The crystal structure of L-lactate oxidase (LOX) from Aerococcus viridans has been determined at 2.1 A resolution. LOX catalyzes the flavin mononucleotide (FMN) dependent oxidation of lactate to pyruvate and hydrogen peroxide. LOX belongs to the alpha-hydroxy-acid oxidase flavoenzyme family; members of which bind similar substrates and to some extent have conserved catalytic properties and structural motifs. LOX crystallized as two tightly packed tetramers in the asymmetric unit, each having fourfold symmetry. The present structure shows a conserved FMN coordination, but also reveals novel residues involved in substrate binding compared with other family members.

About this Structure

2J6X is a Single protein structure of sequence from Aerococcus viridans. Full crystallographic information is available from OCA.

Reference

The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX)., Leiros I, Wang E, Rasmussen T, Oksanen E, Repo H, Petersen SB, Heikinheimo P, Hough E, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1185-90. Epub 2006 Nov 4. PMID:17142893 Page seeded by OCA on Sun May 4 08:26:10 2008

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