2j8h

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[[Image:2j8h.jpg|left|200px]]
[[Image:2j8h.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2j8h |SIZE=350|CAPTION= <scene name='initialview01'>2j8h</scene>, resolution 1.99&Aring;
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The line below this paragraph, containing "STRUCTURE_2j8h", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2j8h| PDB=2j8h | SCENE= }}
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|RELATEDENTRY=[[1bpv|1BPV]], [[1g1c|1G1C]], [[1nct|1NCT]], [[1ncu|1NCU]], [[1tit|1TIT]], [[1tiu|1TIU]], [[1tki|1TKI]], [[1tnm|1TNM]], [[1tnn|1TNN]], [[1waa|1WAA]], [[1ya5|1YA5]], [[2a38|2A38]], [[2bk8|2BK8]], [[2f8v|2F8V]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8h OCA], [http://www.ebi.ac.uk/pdbsum/2j8h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j8h RCSB]</span>
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}}
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'''STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN'''
'''STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN'''
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[[Category: Mueller, S.]]
[[Category: Mueller, S.]]
[[Category: Wilmanns, M.]]
[[Category: Wilmanns, M.]]
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[[Category: a-band]]
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[[Category: A-band]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: cardiomyopathy]]
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[[Category: Cardiomyopathy]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: immunoglobulin like domain]]
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[[Category: Immunoglobulin like domain]]
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[[Category: kelch repeat]]
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[[Category: Kelch repeat]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: limb-girdle muscular dystrophy]]
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[[Category: Limb-girdle muscular dystrophy]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: structural protein]]
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[[Category: Structural protein]]
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[[Category: titin]]
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[[Category: Titin]]
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[[Category: tpr repeat]]
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[[Category: Tpr repeat]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: wd repeat]]
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[[Category: Wd repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:30:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:54:30 2008''
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Revision as of 05:30, 4 May 2008

Image:2j8h.jpg

Template:STRUCTURE 2j8h

STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN


Overview

Most of the structure of the giant muscle protein titin is formed by small modular domains. Many of them are predicted to be arranged in repeats with short linkers that may be key determinants of the peculiar elastic properties of titin. Here, we present the molecular structure of a tandem arrangement of two immunoglobulin-like domains, A168 and A169, located within the A-band segment of titin. The two domains are connected by a 17 residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational flexibility of tandem domain motifs in titin. An unusual bulge within the second domain, A169, is directly involved into binding to a sarcomeric ligand, MURF-1, thus suggesting a dual role of this tandem for both the mechanical properties of titin and for sarcomeric signaling.

About this Structure

2J8H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin., Muller S, Lange S, Gautel M, Wilmanns M, J Mol Biol. 2007 Aug 10;371(2):469-80. Epub 2007 May 25. PMID:17574571 Page seeded by OCA on Sun May 4 08:30:21 2008

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