2j9a

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[[Image:2j9a.gif|left|200px]]
[[Image:2j9a.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2j9a |SIZE=350|CAPTION= <scene name='initialview01'>2j9a</scene>, resolution 1.73&Aring;
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The line below this paragraph, containing "STRUCTURE_2j9a", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AHY:(2S,3R)-3-AMINO-2-HYDROXYDECANOIC+ACID'>AHY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2j9a| PDB=2j9a | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j9a OCA], [http://www.ebi.ac.uk/pdbsum/2j9a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j9a RCSB]</span>
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}}
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'''BLLAP IN COMPLEX WITH MICROGININ FR1'''
'''BLLAP IN COMPLEX WITH MICROGININ FR1'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: Weckesser, J.]]
[[Category: Weckesser, J.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: aminopeptidase]]
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[[Category: Aminopeptidase]]
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[[Category: inhibitor complex hydrolase]]
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[[Category: Inhibitor complex hydrolase]]
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[[Category: leucine aminopeptidase]]
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[[Category: Leucine aminopeptidase]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: microcystin]]
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[[Category: Microcystin]]
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[[Category: microginin]]
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[[Category: Microginin]]
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[[Category: protease]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:32:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:54:54 2008''
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Revision as of 05:32, 4 May 2008

Image:2j9a.gif

Template:STRUCTURE 2j9a

BLLAP IN COMPLEX WITH MICROGININ FR1


Overview

Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors.

About this Structure

2J9A is a Single protein structure of sequence from Bos taurus and Microcystis sp.. Full crystallographic information is available from OCA.

Reference

Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:17157838 Page seeded by OCA on Sun May 4 08:32:57 2008

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