2j9l

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[[Image:2j9l.jpg|left|200px]]
[[Image:2j9l.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2j9l |SIZE=350|CAPTION= <scene name='initialview01'>2j9l</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2j9l", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2j9l| PDB=2j9l | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j9l OCA], [http://www.ebi.ac.uk/pdbsum/2j9l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j9l RCSB]</span>
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}}
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'''CYTOPLASMIC DOMAIN OF THE HUMAN CHLORIDE TRANSPORTER CLC-5 IN COMPLEX WITH ATP'''
'''CYTOPLASMIC DOMAIN OF THE HUMAN CHLORIDE TRANSPORTER CLC-5 IN COMPLEX WITH ATP'''
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[[Category: Meyer, S.]]
[[Category: Meyer, S.]]
[[Category: Savaresi, S.]]
[[Category: Savaresi, S.]]
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[[Category: cbs domain]]
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[[Category: Cbs domain]]
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[[Category: chloride]]
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[[Category: Chloride]]
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[[Category: chloride channel]]
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[[Category: Chloride channel]]
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[[Category: chloride transporter]]
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[[Category: Chloride transporter]]
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[[Category: clc]]
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[[Category: Clc]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: domain]]
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[[Category: Domain]]
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[[Category: ion channel]]
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[[Category: Ion channel]]
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[[Category: ion transport]]
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[[Category: Ion transport]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: transport]]
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[[Category: Transport]]
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[[Category: voltage-gated channel]]
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[[Category: Voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:33:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:55:04 2008''
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Revision as of 05:33, 4 May 2008

Image:2j9l.jpg

Template:STRUCTURE 2j9l

CYTOPLASMIC DOMAIN OF THE HUMAN CHLORIDE TRANSPORTER CLC-5 IN COMPLEX WITH ATP


Overview

The ubiquitous CBS domains, which are found as part of cytoplasmic domains in the ClC family of chloride channels and transporters, have previously been identified as building blocks for regulatory nucleotide-binding sites. Here we report the structures of the cytoplasmic domain of the human transporter ClC-5 in complex with ATP and ADP. The nucleotides bind to a specific site in the protein. As determined by equilibrium dialysis, the affinities for ATP, ADP and AMP are in the high micromolar range. Point mutations that interfere with nucleotide binding change the transport behavior of a ClC-5 mutant expressed in Xenopus laevis oocytes. Our results establish the structural and energetic basis for the interaction of ClC-5 with nucleotides and provide a framework for future investigations.

About this Structure

2J9L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5., Meyer S, Savaresi S, Forster IC, Dutzler R, Nat Struct Mol Biol. 2007 Jan;14(1):60-7. Epub 2006 Dec 31. PMID:17195847 Page seeded by OCA on Sun May 4 08:33:42 2008

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