2jbj

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[[Image:2jbj.gif|left|200px]]
[[Image:2jbj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2jbj |SIZE=350|CAPTION= <scene name='initialview01'>2jbj</scene>, resolution 2.19&Aring;
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The line below this paragraph, containing "STRUCTURE_2jbj", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Cl+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Chain+A'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=BC1:Nag+Binding+Site+For+Chain+A'>BC1</scene>, <scene name='pdbsite=BC2:Nag+Binding+Site+For+Chain+A'>BC2</scene>, <scene name='pdbsite=BC3:Nag+Binding+Site+For+Chain+A'>BC3</scene>, <scene name='pdbsite=BC4:Nag+Binding+Site+For+Chain+A'>BC4</scene>, <scene name='pdbsite=BC5:Nag+Binding+Site+For+Chain+A'>BC5</scene>, <scene name='pdbsite=BC6:Nag+Binding+Site+For+Chain+A'>BC6</scene>, <scene name='pdbsite=BC7:Bma+Binding+Site+For+Chain+A'>BC7</scene>, <scene name='pdbsite=BC8:Man+Binding+Site+For+Chain+A'>BC8</scene> and <scene name='pdbsite=BC9:G88+Binding+Site+For+Chain+A'>BC9</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G88:(2S)-2-(PHOSPHONOMETHYL)PENTANEDIOIC+ACID'>G88</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2jbj| PDB=2jbj | SCENE= }}
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|RELATEDENTRY=[[1z8l|1Z8L]], [[2c6c|2C6C]], [[2c6g|2C6G]], [[2c6p|2C6P]], [[2cij|2CIJ]], [[2jbk|2JBK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbj OCA], [http://www.ebi.ac.uk/pdbsum/2jbj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jbj RCSB]</span>
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}}
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'''MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH 2-PMPA (2-PHOSPHONOMETHYL-PENTANEDIOIC ACID)'''
'''MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH 2-PMPA (2-PHOSPHONOMETHYL-PENTANEDIOIC ACID)'''
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[[Category: Hilgenfeld, R.]]
[[Category: Hilgenfeld, R.]]
[[Category: Mesters, J R.]]
[[Category: Mesters, J R.]]
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[[Category: alternative splicin]]
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[[Category: Alternative splicin]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: antigen]]
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[[Category: Antigen]]
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[[Category: carboxypeptidase]]
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[[Category: Carboxypeptidase]]
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[[Category: dipeptidase]]
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[[Category: Dipeptidase]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: metal- binding]]
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[[Category: Metal- binding]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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[[Category: multifunctional enzyme]]
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[[Category: Multifunctional enzyme]]
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[[Category: naaladase]]
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[[Category: Naaladase]]
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[[Category: neurodegenerative disease]]
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[[Category: Neurodegenerative disease]]
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[[Category: peptidase]]
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[[Category: Peptidase]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: prostate cancer]]
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[[Category: Prostate cancer]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: psma]]
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[[Category: Psma]]
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[[Category: signal-anchor]]
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[[Category: Signal-anchor]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:38:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:55:46 2008''
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Revision as of 05:38, 4 May 2008

Image:2jbj.gif

Template:STRUCTURE 2jbj

MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH 2-PMPA (2-PHOSPHONOMETHYL-PENTANEDIOIC ACID)


Overview

Human glutamate carboxypeptidase II (GCPII) occurs in the central nervous system as well as in human prostate (where it is called prostate-specific membrane antigen; PSMA). Inhibitors of the enzyme have been shown to provide neuroprotection, but may also be useful for the detection, imaging and treatment of prostate cancer. Crystal structures were determined of the extracellular part of GCPII (amino-acid residues 44-750) in complex with two potent inhibitors, quisqualate and 2-PMPA (the strongest GCPII inhibitor to date), at resolutions of 3.0 and 2.2 A, respectively. In addition, models were constructed for binding of the inhibitors willardiine, homoibotenate, L-2-amino-4-phosphonobutanoic acid and L-serine-O-sulfate to the S1' site of the enzyme. The common denominator for high-affinity binding to the S1' site is the formation of two strong salt bridges.

About this Structure

2JBJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA., Mesters JR, Henning K, Hilgenfeld R, Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):508-13. Epub 2007, Mar 16. PMID:17372356 Page seeded by OCA on Sun May 4 08:38:53 2008

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