3ull
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(New page: 200px<br /> <applet load="3ull" size="450" color="white" frame="true" align="right" spinBox="true" caption="3ull, resolution 2.40Å" /> '''HUMAN MITOCHONDRIAL...)
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Revision as of 21:43, 12 November 2007
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HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN
Overview
We solved the crystal structure of the homotetrameric single-stranded DNA, binding (SSB) protein from human mitochondria at a resolution of 2.4 A., The tetramer is formed by two dimers interacting head-to-head and shows D2, symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes, and eukaryotic mitochondria; this is the first report of an atomic, resolution structure of this type of protein. Using biochemical data and, analysis of sequence homologies, we were able to correlate the functional, properties with structure. We propose that ssDNA wraps around the, tetrameric HsmtSSB protein through electropositive channels guided by, flexible loops.
About this Structure
3ULL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution., Yang C, Curth U, Urbanke C, Kang C, Nat Struct Biol. 1997 Feb;4(2):153-7. PMID:9033597
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