2jfg

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[[Image:2jfg.jpg|left|200px]]
[[Image:2jfg.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2jfg |SIZE=350|CAPTION= <scene name='initialview01'>2jfg</scene>, resolution 1.52&Aring;
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The line below this paragraph, containing "STRUCTURE_2jfg", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UMA:URIDINE-5&#39;-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE'>UMA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanine--D-glutamate_ligase UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.9 6.3.2.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2jfg| PDB=2jfg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfg OCA], [http://www.ebi.ac.uk/pdbsum/2jfg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jfg RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF MURD LIGASE IN COMPLEX WITH UMA AND ADP'''
'''CRYSTAL STRUCTURE OF MURD LIGASE IN COMPLEX WITH UMA AND ADP'''
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[[Category: Solmajer, T.]]
[[Category: Solmajer, T.]]
[[Category: Urleb, U.]]
[[Category: Urleb, U.]]
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[[Category: adp]]
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[[Category: Adp]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: cell shape]]
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[[Category: Cell shape]]
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[[Category: cell wall]]
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[[Category: Cell wall]]
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[[Category: ligase]]
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[[Category: Ligase]]
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[[Category: murd ligase]]
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[[Category: Murd ligase]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: peptidoglycan synthesis]]
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[[Category: Peptidoglycan synthesis]]
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[[Category: uma]]
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[[Category: Uma]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:49:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:57:25 2008''
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Revision as of 05:49, 4 May 2008

Image:2jfg.jpg

Template:STRUCTURE 2jfg

CRYSTAL STRUCTURE OF MURD LIGASE IN COMPLEX WITH UMA AND ADP


Overview

Mur ligases play an essential role in the intracellular biosynthesis of bacterial peptidoglycan, the main component of the bacterial cell wall, and represent attractive targets for the design of novel antibacterials. UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) catalyses the addition of D-glutamic acid to the cytoplasmic intermediate UDP-N-acetylmuramoyl-L-alanine (UMA) and is the second in the series of Mur ligases. MurD ligase is highly stereospecific for its substrate, D-glutamic acid (D-Glu). Here, we report the high resolution crystal structures of MurD in complexes with two novel inhibitors designed to mimic the transition state of the reaction, which contain either the D-Glu or the L-Glu moiety. The binding modes of N-sulfonyl-D-Glu and N-sulfonyl-L-Glu derivatives were also characterised kinetically. The results of this study represent an excellent starting point for further development of novel inhibitors of this enzyme.

About this Structure

2JFG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase., Kotnik M, Humljan J, Contreras-Martel C, Oblak M, Kristan K, Herve M, Blanot D, Urleb U, Gobec S, Dessen A, Solmajer T, J Mol Biol. 2007 Jun 29;370(1):107-15. Epub 2007 May 4. PMID:17507028 Page seeded by OCA on Sun May 4 08:49:53 2008

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