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4i1b
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(New page: 200px<br /> <applet load="4i1b" size="450" color="white" frame="true" align="right" spinBox="true" caption="4i1b, resolution 2.0Å" /> '''FUNCTIONAL IMPLICATI...)
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Revision as of 21:44, 12 November 2007
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FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE
Contents |
Overview
The molecular structure of interleukin-1 beta, a hormone-like cytokine, with roles in several disease processes, has been determined at 2.0 A, resolution and refined to a crystallographic R-factor of 0.19. The, framework of this molecule consists of 12 antiparallel beta-strands, exhibiting pseudo-3-fold symmetry. Six of the strands make up a, beta-barrel with polar residues concentrated at either end. Analysis of, the three-dimensional structure, together with results from site-directed, mutagenesis and biochemical and immunological studies, suggest that the, core of the beta-barrel plays an important functional role. A large patch, of charged residues on one end of the barrel is proposed as the binding, surface with which IL-1 interacts with its receptor.
Disease
Known disease associated with this structure: Gastric cancer risk after H. pylori infection OMIM:[147720]
About this Structure
4I1B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Functional implications of interleukin-1 beta based on the three-dimensional structure., Veerapandian B, Gilliland GL, Raag R, Svensson AL, Masui Y, Hirai Y, Poulos TL, Proteins. 1992 Jan;12(1):10-23. PMID:1553379
Page seeded by OCA on Mon Nov 12 23:50:57 2007
