This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jgp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2jgp.gif|left|200px]]
[[Image:2jgp.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2jgp |SIZE=350|CAPTION= <scene name='initialview01'>2jgp</scene>, resolution 1.85&Aring;
+
The line below this paragraph, containing "STRUCTURE_2jgp", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Dio+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Dio+Binding+Site+For+Chain+A'>AC4</scene> and <scene name='pdbsite=AC5:Na+Binding+Site+For+Chain+A'>AC5</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2jgp| PDB=2jgp | SCENE= }}
-
|RELATEDENTRY=[[1dny|1DNY]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgp OCA], [http://www.ebi.ac.uk/pdbsum/2jgp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jgp RCSB]</span>
+
-
}}
+
'''STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC'''
'''STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC'''
Line 30: Line 27:
[[Category: Samel, S A.]]
[[Category: Samel, S A.]]
[[Category: Schoenafinger, G.]]
[[Category: Schoenafinger, G.]]
-
[[Category: antibiotic biosynthesis]]
+
[[Category: Antibiotic biosynthesis]]
-
[[Category: antibiotic]]
+
[[Category: Antibiotic]]
-
[[Category: condensation domain]]
+
[[Category: Condensation domain]]
-
[[Category: ligase]]
+
[[Category: Ligase]]
-
[[Category: multifunctional enzyme]]
+
[[Category: Multifunctional enzyme]]
-
[[Category: nonribosomal peptide synthetase]]
+
[[Category: Nonribosomal peptide synthetase]]
-
[[Category: peptide bond formation]]
+
[[Category: Peptide bond formation]]
-
[[Category: peptidyl carrier domain]]
+
[[Category: Peptidyl carrier domain]]
-
[[Category: phosphopantetheine]]
+
[[Category: Phosphopantetheine]]
-
[[Category: tyrocidine]]
+
[[Category: Tyrocidine]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:53:16 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:57:59 2008''
+

Revision as of 05:53, 4 May 2008

Image:2jgp.gif

Template:STRUCTURE 2jgp

STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC


Overview

The crystal structure of the bidomain PCP-C from modules 5 and 6 of the nonribosomal tyrocidine synthetase TycC was determined at 1.8 A resolution. The bidomain structure reveals a V-shaped condensation domain, the canyon-like active site groove of which is associated with the preceding peptidyl carrier protein (PCP) domain at its donor side. The relative arrangement of the PCP and the peptide bond-forming condensation (C) domain places the active sites approximately 50 A apart. Accordingly, this PCP-C structure represents a conformational state prior to peptide transfer from the donor-PCP to the acceptor-PCP domain, implying the existence of additional states of PCP-C domain interaction during catalysis. Additionally, PCP-C exerts a mode of cyclization activity that mimics peptide bond formation catalyzed by C domains. Based on mutational data and pK value analysis of active site residues, it is suggested that nonribosomal peptide bond formation depends on electrostatic interactions rather than on general acid/base catalysis.

About this Structure

2JGP is a Single protein structure of sequence from Brevibacillus brevis. Full crystallographic information is available from OCA.

Reference

Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase., Samel SA, Schoenafinger G, Knappe TA, Marahiel MA, Essen LO, Structure. 2007 Jul;15(7):781-92. PMID:17637339 Page seeded by OCA on Sun May 4 08:53:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jgp"
Personal tools