2jhn

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[[Image:2jhn.gif|left|200px]]
[[Image:2jhn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2jhn |SIZE=350|CAPTION= <scene name='initialview01'>2jhn</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2jhn", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2jhn| PDB=2jhn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhn OCA], [http://www.ebi.ac.uk/pdbsum/2jhn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jhn RCSB]</span>
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}}
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'''3-METHYLADENINE DNA-GLYCOSYLASE FROM ARCHAEOGLOBUS FULGIDUS'''
'''3-METHYLADENINE DNA-GLYCOSYLASE FROM ARCHAEOGLOBUS FULGIDUS'''
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[[Category: Ruoff, P.]]
[[Category: Ruoff, P.]]
[[Category: Uldal, L.]]
[[Category: Uldal, L.]]
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[[Category: alka]]
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[[Category: Alka]]
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[[Category: archaeoglobus fulgidus]]
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[[Category: Archaeoglobus fulgidus]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: hyperthermophile]]
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[[Category: Hyperthermophile]]
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[[Category: n1-methyladenine]]
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[[Category: N1-methyladenine]]
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[[Category: n3-methylcytosine]]
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[[Category: N3-methylcytosine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:55:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:58:20 2008''
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Revision as of 05:55, 4 May 2008

Image:2jhn.gif

Template:STRUCTURE 2jhn

3-METHYLADENINE DNA-GLYCOSYLASE FROM ARCHAEOGLOBUS FULGIDUS


Overview

N(1)-methyladenine (m(1)A) and N(3)-methylcytosine (m(3)C) are major toxic and mutagenic lesions induced by alkylation in single-stranded DNA. In bacteria and mammals, m(1)A and m(3)C were recently shown to be repaired by AlkB-mediated oxidative demethylation, a direct DNA damage reversal mechanism. No AlkB gene homologues have been identified in Archaea. We report that m(1)A and m(3)C are repaired by the AfAlkA base excision repair glycosylase of Archaeoglobus fulgidus, suggesting a different repair mechanism for these lesions in the third domain of life. In addition, AfAlkA was found to effect a robust excision of 1,N(6)-ethenoadenine. We present a high-resolution crystal structure of AfAlkA, which, together with the characterization of several site-directed mutants, forms a molecular rationalization for the newly discovered base excision activity.

About this Structure

2JHN is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA., Leiros I, Nabong MP, Grosvik K, Ringvoll J, Haugland GT, Uldal L, Reite K, Olsbu IK, Knaevelsrud I, Moe E, Andersen OA, Birkeland NK, Ruoff P, Klungland A, Bjelland S, EMBO J. 2007 Apr 18;26(8):2206-17. Epub 2007 Mar 29. PMID:17396151 Page seeded by OCA on Sun May 4 08:55:52 2008

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OCA

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