2jnb
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2jnb.jpg|left|200px]] | [[Image:2jnb.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2jnb", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_2jnb| PDB=2jnb | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''Solution Structure of RNA-binding protein 15.5K''' | '''Solution Structure of RNA-binding protein 15.5K''' | ||
| Line 27: | Line 24: | ||
[[Category: Flynn, P F.]] | [[Category: Flynn, P F.]] | ||
[[Category: Soss, S E.]] | [[Category: Soss, S E.]] | ||
| - | [[Category: | + | [[Category: Kink-turn rna-binding protein]] |
| - | [[Category: | + | [[Category: Nhpx]] |
| - | [[Category: | + | [[Category: Rna binding protein]] |
| - | [[Category: | + | [[Category: Splicing]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:03:49 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:03, 4 May 2008
Solution Structure of RNA-binding protein 15.5K
Overview
The kink-turn (K-turn) motif is recognized and bound by a family of proteins that act as nucleation factors for ribonucleoparticle assembly. The binding of various proteins to a conserved RNA structural motif known as the K-turn has been shown to be an important component of regulation in the ribosome, in the spliceosome, and in RNA modification. 15.5K is a prototypical example of a K-turn binding protein, which has been shown to bind the 5'-U4 stem-loop of the spliceosome and the box C/D motif. We describe the solution NMR structure of free 15.5K, as well as studies of conformational flexibility from 15N NMR relaxation and H/D exchange experiments. The protein appears well-structured aside from conformational fluctuation in alpha3. Flexibility in fast time scale motions and the observation of limited intermediate and slow motions further characterize the free protein and may suggest local contributions to recognition and binding.
About this Structure
2JNB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Functional implications for a prototypical K-turn binding protein from structural and dynamical studies of 15.5K., Soss SE, Flynn PF, Biochemistry. 2007 Dec 25;46(51):14979-86. Epub 2007 Nov 29. PMID:18044964 Page seeded by OCA on Sun May 4 09:03:49 2008
