2jnr
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2jnr.jpg|left|200px]] | [[Image:2jnr.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2jnr", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_2jnr| PDB=2jnr | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide''' | '''Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2JNR is a [[Single protein]] structure | + | 2JNR is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA]. |
==Reference== | ==Reference== | ||
| Line 39: | Line 36: | ||
[[Category: Standker, L.]] | [[Category: Standker, L.]] | ||
[[Category: Wilhelm, D.]] | [[Category: Wilhelm, D.]] | ||
| - | [[Category: | + | [[Category: Peptide complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:04:51 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:04, 4 May 2008
Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide
Overview
A variety of molecules in human blood have been implicated in the inhibition of HIV-1. However, it remained elusive which circulating natural compounds are most effective in controlling viral replication in vivo. To identify natural HIV-1 inhibitors we screened a comprehensive peptide library generated from human hemofiltrate. The most potent fraction contained a 20-residue peptide, designated VIRUS-INHIBITORY PEPTIDE (VIRIP), corresponding to the C-proximal region of alpha1-antitrypsin, the most abundant circulating serine protease inhibitor. We found that VIRIP inhibits a wide variety of HIV-1 strains including those resistant to current antiretroviral drugs. Further analysis demonstrated that VIRIP blocks HIV-1 entry by interacting with the gp41 fusion peptide and showed that a few amino acid changes increase its antiretroviral potency by two orders of magnitude. Thus, as a highly specific natural inhibitor of the HIV-1 gp41 fusion peptide, VIRIP may lead to the development of another class of antiretroviral drugs.
About this Structure
2JNR is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide., Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F, Cell. 2007 Apr 20;129(2):263-75. PMID:17448989 Page seeded by OCA on Sun May 4 09:04:51 2008
Categories: Single protein | Adermann, K. | Biet, T. | Chaipan, C. | Forssmann, W. | Jiang, S. | Jing, W. | Kirchhoff, F. | Lu, H. | Meyer, B. | Munch, J. | Peters, T. | Pohlmann, S. | Schulz, A. | Standker, L. | Wilhelm, D. | Peptide complex
