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7i1b
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(New page: 200px<br /> <applet load="7i1b" size="450" color="white" frame="true" align="right" spinBox="true" caption="7i1b" /> '''HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE...)
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Revision as of 21:46, 12 November 2007
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HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN-1 BETA IN SOLUTION BY THREE-AND FOUR-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Contents |
Overview
The determination of the high-resolution three-dimensional solution, structure of interleukin 1 beta (IL-1 beta), a protein of 153 residues and, 17.4 kDa, which plays a central role in the immune and inflammatory, responses, has been determined by heteronuclear (13C and 15N) three- and, four-dimensional NMR spectroscopy. The structure is based on 3146, experimental restraints comprising 2780 distance and 366 torsion angle, (phi, psi, and chi 1) restraints. A total of 32 simulated annealing, structures are calculated, and the atomic RMS distribution about the mean, coordinate positions is 0.41 +/- 0.04 A for the backbone atoms and 0.82, +/- 0.04 A for all atoms (excluding residue 1 at the N-terminus and, residues 152 and 153 at the C-terminus, which are partially disordered)., In the case of internal side chains with a surface accessibility of less, than or equal to 40%, the atomic RMS distribution about the mean, coordinate positions for all atoms is 0.49 +/- 0.03 A. IL-1 beta resembles, a tetrahedron and is composed of 12 beta-strands arranged in three, pseudosymmetric topological units, each of which comprises 5 strands., Analysis of the mutational data on IL-1 beta in the light of the, three-dimensional structure suggests the presence of three distinct, binding sites for the IL-1 receptor on the surface of the protein. It is, suggested that each of the three immunoglobulin domains which comprise the, extracellular portion of the IL-1 receptor recognizes one of these sites.
Disease
Known disease associated with this structure: Gastric cancer risk after H. pylori infection OMIM:[147720]
About this Structure
7I1B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy., Clore GM, Wingfield PT, Gronenborn AM, Biochemistry. 1991 Mar 5;30(9):2315-23. PMID:2001363
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