2jo7
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2jo7.jpg|left|200px]] | [[Image:2jo7.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2jo7", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_2jo7| PDB=2jo7 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Solution structure of the adhesion protein Bd37 from Babesia divergens''' | '''Solution structure of the adhesion protein Bd37 from Babesia divergens''' | ||
| Line 34: | Line 31: | ||
[[Category: Schetters, T.]] | [[Category: Schetters, T.]] | ||
[[Category: Yang, Y.]] | [[Category: Yang, Y.]] | ||
| - | [[Category: | + | [[Category: Babesia divergen]] |
| - | [[Category: | + | [[Category: Gpi-anchored protein]] |
| - | [[Category: | + | [[Category: Recombinant vaccine]] |
| - | [[Category: | + | [[Category: Surface active protein]] |
| - | [[Category: | + | [[Category: Surface antigen]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:06:06 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:06, 4 May 2008
Solution structure of the adhesion protein Bd37 from Babesia divergens
Overview
Babesia divergens is the Apicomplexa agent of the bovine babesiosis in Europe: this infection leads to growth and lactation decrease, so that economical losses due to this parasite are sufficient to require the development of a vaccine. The major surface antigen of B. divergens has been described as a 37 kDa protein glycosyl phosphatidyl inositol (GPI)-anchored at the surface of the merozoite. The immuno-prophylactic potential of Bd37 has been demonstrated, and we present here the high-resolution solution structure of the 27 kDa structured core of Bd37 (Delta-Bd37) using NMR spectroscopy. A model for the whole protein has been obtained using additional small angle X-ray scattering (SAXS) data. The knowledge of the 3D structure of Bd37 allowed the precise epitope mapping of antibodies on its surface. Interestingly, the geometry of Delta-Bd37 reveals an intriguing similarity with the exocyst subunit Exo84p C-terminal region, an eukaryotic protein that has a direct implication in vesicle trafficking. This strongly suggests that Apicomplexa have developed in parallel molecular machines similar in structure and function to the ones used for endo- and exocytosis in eukaryotic cells.
About this Structure
2JO7 is a Single protein structure of sequence from Babesia divergens. Full crystallographic information is available from OCA.
Reference
The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking., Delbecq S, Auguin D, Yang YS, Lohr F, Arold S, Schetters T, Precigout E, Gorenflot A, Roumestand C, J Mol Biol. 2008 Jan 11;375(2):409-24. Epub 2007 Aug 21. PMID:18035372 Page seeded by OCA on Sun May 4 09:06:06 2008
