2joo

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2joo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2joo OCA], [http://www.ebi.ac.uk/pdbsum/2joo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2joo RCSB]</span>
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'''The NMR Solution Structure of Recombinant RGD-hirudin'''
'''The NMR Solution Structure of Recombinant RGD-hirudin'''
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[[Category: Song, X.]]
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[[Category: Yan, X.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:07:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:00:07 2008''
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Revision as of 06:07, 4 May 2008

Image:2joo.jpg

Template:STRUCTURE 2joo

The NMR Solution Structure of Recombinant RGD-hirudin


Overview

The solution structure of a new recombinant RGD-hirudin, which has the activities of anti-thrombin and anti-platelet aggregation, was determined by (1)H nuclear magnetic resonance spectroscopy and compared with the conformations of recombinant wild-type hirudin and hirudin (variant 2, Lys47) of the hirudin thrombin complex. On the basis of total 1284 distance and dihedral angle constraints derived from a series of NMR spectra, 20 conformers were computed with ARIA/CNS programs. The structure of residues 3-30 and 37-48 form a molecular core with two antiparallel beta-sheets as the other two hirudins. However, significant differences were found in the surface electrostatic charge distributions among the three hirudins, especially in the RGD segment of recombinant RGD-hirudin. This difference may be greatly beneficial to its additional function of anti-platelet aggregation. The difference in extended C-terminal makes its both ionic and hydrophobic interactions with the fibrinogen recognition exosite of thrombin more effective.

About this Structure

2JOO is a Single protein structure of sequence from Hirudo medicinalis. Full crystallographic information is available from OCA.

Reference

The NMR solution structure of recombinant RGD-hirudin., Song X, Mo W, Liu X, Zhu L, Yan X, Song H, Dai L, Biochem Biophys Res Commun. 2007 Aug 17;360(1):103-8. Epub 2007 Jun 13. PMID:17585879 Page seeded by OCA on Sun May 4 09:07:23 2008

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