2jpz

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[[Image:2jpz.gif|left|200px]]
[[Image:2jpz.gif|left|200px]]
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{{Structure
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|PDB= 2jpz |SIZE=350|CAPTION= <scene name='initialview01'>2jpz</scene>
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The line below this paragraph, containing "STRUCTURE_2jpz", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_2jpz| PDB=2jpz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpz OCA], [http://www.ebi.ac.uk/pdbsum/2jpz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jpz RCSB]</span>
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'''Structure of the hybrid-2 type intramolecular human telomeric G-quadruplex'''
'''Structure of the hybrid-2 type intramolecular human telomeric G-quadruplex'''
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==About this Structure==
==About this Structure==
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2JPZ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPZ OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPZ OCA].
==Reference==
==Reference==
Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence., Dai J, Carver M, Punchihewa C, Jones RA, Yang D, Nucleic Acids Res. 2007;35(15):4927-40. Epub 2007 Jul 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17626043 17626043]
Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence., Dai J, Carver M, Punchihewa C, Jones RA, Yang D, Nucleic Acids Res. 2007;35(15):4927-40. Epub 2007 Jul 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17626043 17626043]
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[[Category: Protein complex]]
 
[[Category: Carver, M.]]
[[Category: Carver, M.]]
[[Category: Dai, J.]]
[[Category: Dai, J.]]
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[[Category: Punchihewa, C.]]
[[Category: Punchihewa, C.]]
[[Category: Yang, D.]]
[[Category: Yang, D.]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: human telomeric sequence]]
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[[Category: Human telomeric sequence]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: quadruplex]]
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[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:10:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:00:48 2008''
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Revision as of 06:10, 4 May 2008

Image:2jpz.gif

Template:STRUCTURE 2jpz

Structure of the hybrid-2 type intramolecular human telomeric G-quadruplex


Overview

Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomerase, thus the intramolecular telomeric G-quadruplexes have been considered as an attractive anticancer target. Information of intramolecular telomeric G-quadruplex structures formed under physiological conditions is important for structure-based drug design. Here, we report the first structure of the major intramolecular G-quadruplex formed in a native, non-modified human telomeric sequence in K(+) solution. This is a hybrid-type mixed parallel/antiparallel-G-stranded G-quadruplex, one end of which is covered by a novel T:A:T triple capping structure. This structure (Hybrid-2) and the previously reported Hybrid-1 structure differ in their loop arrangements, strand orientations and capping structures. The distinct capping structures appear to be crucial for the favored formation of the specific hybrid-type intramolecular telomeric G-quadruplexes, and may provide specific binding sites for drug targeting. Our study also shows that while the hybrid-type G-quadruplexes appear to be the major conformations in K(+) solution, human telomeric sequences are always in equilibrium between Hybrid-1 and Hybrid-2 structures, which is largely determined by the 3'-flanking sequence. Furthermore, both hybrid-type G-quadruplexes suggest a straightforward means for multimer formation with effective packing in the human telomeric sequence and provide important implications for drug targeting of G-quadruplexes in human telomeres.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence., Dai J, Carver M, Punchihewa C, Jones RA, Yang D, Nucleic Acids Res. 2007;35(15):4927-40. Epub 2007 Jul 10. PMID:17626043 Page seeded by OCA on Sun May 4 09:10:15 2008

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