2jsb
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2jsb.jpg|left|200px]] | [[Image:2jsb.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2jsb", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_2jsb| PDB=2jsb | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Solution structure of arenicin-1''' | '''Solution structure of arenicin-1''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2JSB is a [[Single protein]] structure | + | 2JSB is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSB OCA]. |
==Reference== | ==Reference== | ||
| Line 31: | Line 28: | ||
[[Category: Krasnosdembskaya, A D.]] | [[Category: Krasnosdembskaya, A D.]] | ||
[[Category: Leippe, M.]] | [[Category: Leippe, M.]] | ||
| - | [[Category: | + | [[Category: Antimicrobial]] |
| - | [[Category: | + | [[Category: Antimicrobial protein]] |
| - | [[Category: | + | [[Category: Arenicin]] |
| - | [[Category: | + | [[Category: Arenicin-1]] |
| - | [[Category: | + | [[Category: Arenicola marina]] |
| - | [[Category: | + | [[Category: Nmr]] |
| - | [[Category: | + | [[Category: Peptide]] |
| - | [[Category: | + | [[Category: Poreforming]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:15:05 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:15, 4 May 2008
Solution structure of arenicin-1
Overview
The solution structure and the mode of action of arenicin isoform 1, an antimicrobial peptide with a unique 18-residue loop structure, from the lugworm Arenicola marina were elucidated here. Arenicin folds into a two-stranded antiparallel beta-sheet. It exhibits high antibacterial activity at 37 and 4 degrees C against Gram-negative bacteria, including polymyxin B-resistant Proteus mirabilis. Bacterial killing occurs within minutes and is accompanied by membrane permeabilization, membrane detachment and release of cytoplasm. Interaction of arenicin with reconstituted membranes that mimic the lipopolysaccharide-containing outer membrane or the phospholipid-containing plasma membrane of Gram-negative bacteria exhibited no pronounced lipid specificity. Arenicin-induced current fluctuations in planar lipid bilayers correspond to the formation of short-lived heterogeneously structured lesions. Our results strongly suggest that membrane interaction plays a pivotal role in the antibacterial activity of arenicin.
About this Structure
2JSB is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structure and mode of action of the antimicrobial peptide arenicin., Andra J, Jakovkin I, Grotzinger J, Hecht O, Krasnosdembskaya AD, Goldmann T, Gutsmann T, Leippe M, Biochem J. 2008 Feb 15;410(1):113-22. PMID:17935487 Page seeded by OCA on Sun May 4 09:15:05 2008
