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2jv0

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[[Image:2jv0.jpg|left|200px]]
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{{Structure
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|PDB= 2jv0 |SIZE=350|CAPTION= <scene name='initialview01'>2jv0</scene>
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The line below this paragraph, containing "STRUCTURE_2jv0", creates the "Structure Box" on the page.
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|GENE= PRDM2, RIZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2jv0| PDB=2jv0 | SCENE= }}
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|RELATEDENTRY=[[2qpw|2QPW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jv0 OCA], [http://www.ebi.ac.uk/pdbsum/2jv0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jv0 RCSB]</span>
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'''SET domain of RIZ1 tumor suppressor (PRDM2)'''
'''SET domain of RIZ1 tumor suppressor (PRDM2)'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Briknarova, K.]]
[[Category: Briknarova, K.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: alternative initiation]]
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[[Category: Alternative initiation]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: histone lysine methyltransferase]]
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[[Category: Histone lysine methyltransferase]]
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[[Category: hkmt]]
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[[Category: Hkmt]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: pr domain]]
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[[Category: Pr domain]]
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[[Category: prdm2]]
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[[Category: Prdm2]]
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[[Category: protein lysine methyltransferase]]
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[[Category: Protein lysine methyltransferase]]
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[[Category: riz1]]
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[[Category: Riz1]]
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[[Category: set domain]]
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[[Category: Set domain]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: zinc]]
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[[Category: Zinc]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:19:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:01:54 2008''
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Revision as of 06:19, 4 May 2008

Image:2jv0.jpg

Template:STRUCTURE 2jv0

SET domain of RIZ1 tumor suppressor (PRDM2)


Overview

RIZ1 is a transcriptional regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3. It contains a distinct SET domain, sometimes referred to as PR (PRDI-BF1 and RIZ1 homology) domain, that is responsible for its catalytic activity. We determined the solution structure of the PR domain from RIZ1 and characterized its interaction with S-adenosyl-l-homocysteine (SAH) and a peptide from histone H3. Despite low sequence identity with canonical SET domains, the PR domain displays a typical SET fold including a pseudo-knot at the C-terminus. The N-flanking sequence of RIZ1 PR domain adopts a novel conformation and interacts closely with the SET fold. The C-flanking sequence contains an alpha-helix that points away from the protein face that harbors active site in other SET domains. The SET fold of RIZ1 does not have detectable affinity for SAH but it interacts with a synthetic peptide comprising residues 1-20 of histone H3.

About this Structure

2JV0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural studies of the SET domain from RIZ1 tumor suppressor., Briknarova K, Zhou X, Satterthwait A, Hoyt DW, Ely KR, Huang S, Biochem Biophys Res Commun. 2008 Feb 15;366(3):807-13. Epub 2007 Dec 17. PMID:18082620 Page seeded by OCA on Sun May 4 09:19:11 2008

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