2jwa

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[[Image:2jwa.jpg|left|200px]]
[[Image:2jwa.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2jwa |SIZE=350|CAPTION= <scene name='initialview01'>2jwa</scene>
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The line below this paragraph, containing "STRUCTURE_2jwa", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ERBB2, HER2, NEU, NGL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2jwa| PDB=2jwa | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwa OCA], [http://www.ebi.ac.uk/pdbsum/2jwa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jwa RCSB]</span>
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}}
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'''ErbB2 transmembrane segment dimer spatial structure'''
'''ErbB2 transmembrane segment dimer spatial structure'''
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[[Category: Bocharov, E V.]]
[[Category: Bocharov, E V.]]
[[Category: Mineev, K S.]]
[[Category: Mineev, K S.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: erbb2]]
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[[Category: Erbb2]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: protein kinase receptor membrane domain]]
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[[Category: Protein kinase receptor membrane domain]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transmembrane helix dimer]]
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[[Category: Transmembrane helix dimer]]
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[[Category: tyrosine-protein kinase]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:20:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:02:10 2008''
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Revision as of 06:20, 4 May 2008

Image:2jwa.jpg

Template:STRUCTURE 2jwa

ErbB2 transmembrane segment dimer spatial structure


Overview

Proper lateral dimerization of transmembrane domain of receptor tyrosine kinases is required for biochemical signal transduction across plasma membrane. Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelle was obtained by solution NMR followed by molecular dynamics relaxation in explicit lipid bilayer. ErbB2 transmembrane segments associate in a right-handed alpha-helical bundle through the N-terminal tandem GG4-like motif T(652)X(3)S(656)X(3)G(660), providing explanation for pathogenic power of some oncogenic mutations.

About this Structure

2JWA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state., Bocharov EV, Mineev KS, Volynsky PE, Ermolyuk YS, Tkach EN, Sobol AG, Chupin VV, Kirpichnikov MP, Efremov RG, Arseniev AS, J Biol Chem. 2008 Jan 4;. PMID:18178548 Page seeded by OCA on Sun May 4 09:20:56 2008

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OCA

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