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2jwq
From Proteopedia
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[[Image:2jwq.jpg|left|200px]] | [[Image:2jwq.jpg|left|200px]] | ||
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'''G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study''' | '''G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JWQ is a [[Single protein]] structure | + | 2JWQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Saettel, N.]] | [[Category: Saettel, N.]] | ||
[[Category: Teulade-Fichou, M.]] | [[Category: Teulade-Fichou, M.]] | ||
| - | [[Category: | + | [[Category: Dna]] |
| - | [[Category: | + | [[Category: G-quadruplex]] |
| - | [[Category: | + | [[Category: Quinacridine]] |
| - | [[Category: | + | [[Category: Telomerase inhibitor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:21:40 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:21, 4 May 2008
G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study
Overview
The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.
About this Structure
2JWQ is a Single protein structure. Full crystallographic information is available from OCA.
Reference
G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study., Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP, ChemMedChem. 2007 May;2(5):655-66. PMID:17385760 Page seeded by OCA on Sun May 4 09:21:40 2008
