2jyd

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[[Image:2jyd.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyd OCA], [http://www.ebi.ac.uk/pdbsum/2jyd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jyd RCSB]</span>
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'''Structure of the fifth zinc finger of Myelin Transcription Factor 1'''
'''Structure of the fifth zinc finger of Myelin Transcription Factor 1'''
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[[Category: Matthews, J M.]]
[[Category: Matthews, J M.]]
[[Category: Swanton, M K.]]
[[Category: Swanton, M K.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: developmental protein]]
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[[Category: Developmental protein]]
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[[Category: differentiation]]
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[[Category: Differentiation]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: metal binding protein]]
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[[Category: Metal binding protein]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: myt1]]
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[[Category: Myt1]]
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[[Category: neurogenesis]]
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[[Category: Neurogenesis]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:24:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:02:32 2008''
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Revision as of 06:24, 4 May 2008

Image:2jyd.jpg

Template:STRUCTURE 2jyd

Structure of the fifth zinc finger of Myelin Transcription Factor 1


Overview

Zinc binding domains, or zinc fingers (ZnFs), form one of the most numerous and most diverse superclasses of protein structural motifs in eukaryotes. Although our understanding of the functions of several classes of these domains is relatively well developed, we know much less about the molecular mechanisms of action of many others. Myelin transcription factor 1 (MyT1) type ZnFs are found in organisms as diverse as nematodes and mammals and are found in a range of sequence contexts. MyT1, one of the early transcription factors expressed in the developing central nervous system, contains seven MyT1 ZnFs that are very highly conserved both within the protein and between species. We have used a range of biophysical techniques, including NMR spectroscopy and data-driven macromolecular docking, to investigate the structural basis for the interaction between MyT1 ZnFs and DNA. Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.

About this Structure

2JYD is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1., Gamsjaeger R, Swanton MK, Kobus FJ, Lehtomaki E, Lowry JA, Kwan AH, Matthews JM, Mackay JP, J Biol Chem. 2008 Feb 22;283(8):5158-67. Epub 2007 Dec 11. PMID:18073212 Page seeded by OCA on Sun May 4 09:24:06 2008

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