2np2

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[[Image:2np2.gif|left|200px]]
[[Image:2np2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2np2 |SIZE=350|CAPTION= <scene name='initialview01'>2np2</scene>, resolution 3.02&Aring;
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The line below this paragraph, containing "STRUCTURE_2np2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= hbb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])
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-->
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|DOMAIN=
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{{STRUCTURE_2np2| PDB=2np2 | SCENE= }}
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|RELATEDENTRY=[[1ihf|1IHF]], [[1p78|1P78]], [[1p71|1P71]], [[1p51|1P51]], [[1b8z|1B8Z]], [[1owf|1OWF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2np2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2np2 OCA], [http://www.ebi.ac.uk/pdbsum/2np2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2np2 RCSB]</span>
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}}
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'''Hbb-DNA complex'''
'''Hbb-DNA complex'''
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[[Category: Mouw, K W.]]
[[Category: Mouw, K W.]]
[[Category: Rice, P A.]]
[[Category: Rice, P A.]]
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[[Category: dna-bending protein]]
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[[Category: Dna-bending protein]]
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[[Category: dna-binding protein]]
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[[Category: Dna-binding protein]]
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[[Category: dnabii family]]
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[[Category: Dnabii family]]
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[[Category: hu/ihf family]]
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[[Category: Hu/ihf family]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:43:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:06:18 2008''
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Revision as of 06:43, 4 May 2008

Image:2np2.gif

Template:STRUCTURE 2np2

Hbb-DNA complex


Overview

The genome of the Lyme disease-causing spirochete Borrelia burgdorferi encodes only a single polypeptide from the integration host factor (IHF)/HU or 'DNABII' family of nucleoid-associated proteins - Hbb. DNABII proteins induce large bends in DNA and serve as architectural factors in a variety of prokaryotic cellular processes. We have solved the crystal structure of an Hbb-DNA complex in which the DNA is bent by over 180 degrees . We find that like IHF, Hbb relies exclusively on indirect readout to recognize its cognate site. Additional binding studies show that the sequence preferences of Hbb are related to, yet distinct from those of IHF. Defining these binding characteristics may help to uncover additional roles for Hbb in Borrelia DNA metabolism as well as further our understanding of the mechanism of indirect readout.

About this Structure

2NP2 is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

Shaping the Borrelia burgdorferi genome: crystal structure and binding properties of the DNA-bending protein Hbb., Mouw KW, Rice PA, Mol Microbiol. 2007 Mar;63(5):1319-30. Epub 2007 Jan 22. PMID:17244195 Page seeded by OCA on Sun May 4 09:43:46 2008

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OCA

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