2npa

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[[Image:2npa.gif|left|200px]]
[[Image:2npa.gif|left|200px]]
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{{Structure
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|PDB= 2npa |SIZE=350|CAPTION= <scene name='initialview01'>2npa</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2npa", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MMB:(2R,3E)-2-{4-[(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHOXY]BENZYL}-3-(PROPOXYIMINO)BUTANOIC+ACID'>MMB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|DOMAIN=
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{{STRUCTURE_2npa| PDB=2npa | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npa OCA], [http://www.ebi.ac.uk/pdbsum/2npa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2npa RCSB]</span>
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}}
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'''the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid'''
'''the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid'''
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[[Category: Kim, S H.]]
[[Category: Kim, S H.]]
[[Category: Koh, J S.]]
[[Category: Koh, J S.]]
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[[Category: protein-agonist complex]]
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[[Category: Protein-agonist complex]]
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[[Category: transcription]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:44:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:06:20 2008''
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Revision as of 06:44, 4 May 2008

Image:2npa.gif

Template:STRUCTURE 2npa

the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid


Overview

Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.

About this Structure

2NPA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists., Oon Han H, Kim SH, Kim KH, Hur GC, Joo Yim H, Chung HK, Ho Woo S, Dong Koo K, Lee CS, Sung Koh J, Kim GT, Bioorg Med Chem Lett. 2007 Feb 15;17(4):937-41. Epub 2006 Nov 18. PMID:17157019 Page seeded by OCA on Sun May 4 09:44:11 2008

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OCA

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