2npl

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[[Image:2npl.gif|left|200px]]
[[Image:2npl.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2npl", creates the "Structure Box" on the page.
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|GENE= CXADR, CAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2npl| PDB=2npl | SCENE= }}
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|RELATEDENTRY=[[1rsf|1RSF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npl OCA], [http://www.ebi.ac.uk/pdbsum/2npl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2npl RCSB]</span>
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'''NMR Structure of CARD d2 Domain'''
'''NMR Structure of CARD d2 Domain'''
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[[Category: Caffrey, M.]]
[[Category: Caffrey, M.]]
[[Category: Jiang, S.]]
[[Category: Jiang, S.]]
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[[Category: coxsakievirus and adenovirus receptor]]
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[[Category: Coxsakievirus and adenovirus receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:44:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:06:28 2008''
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Revision as of 06:44, 4 May 2008

Image:2npl.gif

Template:STRUCTURE 2npl

NMR Structure of CARD d2 Domain


Overview

The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.

About this Structure

2NPL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the coxsackievirus and adenovirus receptor domain 2., Jiang S, Caffrey M, Protein Sci. 2007 Mar;16(3):539-42. PMID:17322536 Page seeded by OCA on Sun May 4 09:44:48 2008

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