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2nq2
From Proteopedia
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'''An inward-facing conformation of a putative metal-chelate type ABC transporter.''' | '''An inward-facing conformation of a putative metal-chelate type ABC transporter.''' | ||
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[[Category: Pinkett, H P.]] | [[Category: Pinkett, H P.]] | ||
[[Category: Rees, D C.]] | [[Category: Rees, D C.]] | ||
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| - | [[Category: | + | [[Category: Nucleotide binding domain]] |
| - | [[Category: | + | [[Category: Putative iron chelatin abc transporter]] |
| - | [[Category: | + | [[Category: Transmembrane domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:46:07 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:46, 4 May 2008
An inward-facing conformation of a putative metal-chelate type ABC transporter.
Overview
The crystal structure of a putative metal-chelate-type adenosine triphosphate (ATP)-binding cassette (ABC) transporter encoded by genes HI1470 and HI1471 of Haemophilus influenzae has been solved at 2.4 angstrom resolution. The permeation pathway exhibits an inward-facing conformation, in contrast to the outward-facing state previously observed for the homologous vitamin B12 importer BtuCD. Although the structures of both HI1470/1 and BtuCD have been solved in nucleotide-free states, the pairs of ABC subunits in these two structures differ by a translational shift in the plane of the membrane that coincides with a repositioning of the membrane-spanning subunits. The differences observed between these ABC transporters involve relatively modest rearrangements and may serve as structural models for inward- and outward-facing conformations relevant to the alternating access mechanism of substrate translocation.
About this Structure
2NQ2 is a Protein complex structure of sequences from Haemophilus influenzae. Full crystallographic information is available from OCA.
Reference
An inward-facing conformation of a putative metal-chelate-type ABC transporter., Pinkett HW, Lee AT, Lum P, Locher KP, Rees DC, Science. 2007 Jan 19;315(5810):373-7. Epub 2006 Dec 7. PMID:17158291 Page seeded by OCA on Sun May 4 09:46:07 2008
