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2nqc

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqc OCA], [http://www.ebi.ac.uk/pdbsum/2nqc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nqc RCSB]</span>
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'''Crystal structure of ig-like domain 23 from human filamin C'''
'''Crystal structure of ig-like domain 23 from human filamin C'''
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[[Category: Svergun, D.]]
[[Category: Svergun, D.]]
[[Category: Ylanne, J.]]
[[Category: Ylanne, J.]]
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[[Category: filamin]]
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[[Category: Filamin]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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[[Category: metal binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:46:43 2008''
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Revision as of 06:46, 4 May 2008

Image:2nqc.jpg


PDB ID 2nqc

Drag the structure with the mouse to rotate
2nqc, resolution 2.05Å ()
Ligands: , ,
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal structure of ig-like domain 23 from human filamin C


Overview

Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation experiments on the constructs containing carboxy-terminal domains of the protein (domains 23-24 and 19-21). The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. Small-angle X-ray scattering experiments performed on filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed by domain 24 and that domain 23 has little interactions with itself or with domain 24, while the analytical ultracentrifugation experiments showed that the filamin C domains 19-21 form elongated monomers in diluted solutions.

About this Structure

2NQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Djinovic Carugo K, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:17379241 Page seeded by OCA on Sun May 4 09:46:43 2008

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