2nry

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[[Image:2nry.jpg|left|200px]]
[[Image:2nry.jpg|left|200px]]
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{{Structure
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|PDB= 2nry |SIZE=350|CAPTION= <scene name='initialview01'>2nry</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_2nry", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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{{STRUCTURE_2nry| PDB=2nry | SCENE= }}
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|RELATEDENTRY=[[2nru|2NRU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nry OCA], [http://www.ebi.ac.uk/pdbsum/2nry PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nry RCSB]</span>
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'''Crystal structure of IRAK-4'''
'''Crystal structure of IRAK-4'''
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[[Category: Walker, N P.C.]]
[[Category: Walker, N P.C.]]
[[Category: Wang, Z.]]
[[Category: Wang, Z.]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: staurosporine]]
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[[Category: Staurosporine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:50:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:07:25 2008''
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Revision as of 06:50, 4 May 2008

Image:2nry.jpg

Template:STRUCTURE 2nry

Crystal structure of IRAK-4


Overview

Interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4) is a serine/threonine kinase that plays an essential role in signal transduction by Toll/IL-1 receptors (TIRs). Here, we report the crystal structures of the phosphorylated human IRAK-4 kinase domain in complex with a potent inhibitor and with staurosporine to 2.0 and 2.2 A, respectively. The structures reveal that IRAK-4 has a unique tyrosine gatekeeper residue that interacts with the conserved glutamate from helix alphaC. Consequently, helix alphaC is "pulled in" to maintain the active orientation, and the usual pre-existing hydrophobic back pocket of the ATP-binding site is abolished. The peptide substrate-binding site is more open when compared with other protein kinases due to a marked movement of helix alphaG. The pattern of phosphate ligand interactions in the activation loop bears a close resemblance to that of a tyrosine kinase. Our results provide insights into IRAK-4 function and the design of selective inhibitors.

About this Structure

2NRY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper., Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP, Structure. 2006 Dec;14(12):1835-44. PMID:17161373 Page seeded by OCA on Sun May 4 09:50:10 2008

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