2nts

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[[Image:2nts.gif|left|200px]]
[[Image:2nts.gif|left|200px]]
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{{Structure
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|PDB= 2nts |SIZE=350|CAPTION= <scene name='initialview01'>2nts</scene>, resolution 2.400&Aring;
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The line below this paragraph, containing "STRUCTURE_2nts", creates the "Structure Box" on the page.
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|SITE=
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|GENE= TRBC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), sek ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
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{{STRUCTURE_2nts| PDB=2nts | SCENE= }}
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|RELATEDENTRY=[[2ntt|2NTT]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nts OCA], [http://www.ebi.ac.uk/pdbsum/2nts PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nts RCSB]</span>
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'''Crystal Structure of SEK-hVb5.1'''
'''Crystal Structure of SEK-hVb5.1'''
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[[Category: Sundberg, E J.]]
[[Category: Sundberg, E J.]]
[[Category: Varma, A K.]]
[[Category: Varma, A K.]]
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[[Category: superantigen]]
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[[Category: Superantigen]]
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[[Category: t cell receptor]]
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[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:54:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:08:18 2008''
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Revision as of 06:54, 4 May 2008

Image:2nts.gif

Template:STRUCTURE 2nts

Crystal Structure of SEK-hVb5.1


Overview

Superantigens (SAGs) interact with host immune receptors to induce a massive release of inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can be classified into five distinct evolutionary groups. Group V SAGs are characterized by the alpha3-beta8 loop, a unique approximately 15 amino acid residue extension that is required for optimal T cell activation. Here, we report the X-ray crystal structures of the group V SAG staphylococcal enterotoxin K (SEK) alone and in complex with the TCR hVbeta5.1 domain. SEK adopts a unique TCR binding orientation relative to other SAG-TCR complexes, which results in the alpha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR recognition site of SAGs. These interactions are absolutely required for TCR binding and T cell activation by SEK, and dictate the TCR Vbeta domain specificity of SEK and other group V SAGs.

About this Structure

2NTS is a Single protein structure of sequence from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A novel loop domain in superantigens extends their T cell receptor recognition site., Gunther S, Varma AK, Moza B, Kasper KJ, Wyatt AW, Zhu P, Rahman AK, Li Y, Mariuzza RA, McCormick JK, Sundberg EJ, J Mol Biol. 2007 Aug 3;371(1):210-21. Epub 2007 May 18. PMID:17560605 Page seeded by OCA on Sun May 4 09:54:04 2008

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