2num

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2num.jpg|left|200px]]
[[Image:2num.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2num |SIZE=350|CAPTION= <scene name='initialview01'>2num</scene>, resolution 1.50&Aring;
+
The line below this paragraph, containing "STRUCTURE_2num", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= petA, fbcF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1063 Rhodobacter sphaeroides])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2num| PDB=2num | SCENE= }}
-
|RELATEDENTRY=[[2nuk|2NUK]], [[2nve|2NVE]], [[2nvf|2NVF]], [[2nvg|2NVG]], [[2nwf|2NWF]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2num FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2num OCA], [http://www.ebi.ac.uk/pdbsum/2num PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2num RCSB]</span>
+
-
}}
+
'''Soluble domain of Rieske Iron-Sulfur Protein'''
'''Soluble domain of Rieske Iron-Sulfur Protein'''
Line 31: Line 28:
[[Category: Lhee, S.]]
[[Category: Lhee, S.]]
[[Category: Nair, S K.]]
[[Category: Nair, S K.]]
-
[[Category: iron sulfur cluster]]
+
[[Category: Iron sulfur cluster]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:55:53 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:08:39 2008''
+

Revision as of 06:55, 4 May 2008

Image:2num.jpg

Template:STRUCTURE 2num

Soluble domain of Rieske Iron-Sulfur Protein


Overview

The Rieske [2Fe-2S] iron-sulfur protein of cytochrome bc(1) functions as the initial electron acceptor in the rate-limiting step of the catalytic reaction. Prior studies have established roles for a number of conserved residues that hydrogen bond to ligands of the [2Fe-2S] cluster. We have constructed site-specific variants at two of these residues, measured their thermodynamic and functional properties, and determined atomic resolution X-ray crystal structures for the native protein at 1.2 A resolution and for five variants (Ser-154-->Ala, Ser-154-->Thr, Ser-154-->Cys, Tyr-156-->Phe, and Tyr-156-->Trp) to resolutions between 1.5 A and 1.1 A. These structures and complementary biophysical data provide a molecular framework for understanding the role hydrogen bonds to the cluster play in tuning thermodynamic properties, and hence the rate of this bioenergetic reaction. These studies provide a detailed structure-function dissection of the role of hydrogen bonds in tuning the redox potentials of [2Fe-2S] clusters.

About this Structure

2NUM is a Single protein structure of sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters., Kolling DJ, Brunzelle JS, Lhee S, Crofts AR, Nair SK, Structure. 2007 Jan;15(1):29-38. PMID:17223530 Page seeded by OCA on Sun May 4 09:55:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2num"
Personal tools