1bgw
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(New page: 200px<br /> <applet load="1bgw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bgw, resolution 2.7Å" /> '''TOPOISOMERASE RESIDU...)
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Revision as of 06:50, 18 November 2007
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TOPOISOMERASE RESIDUES 410-1202,
Overview
The crystal structure of a large fragment of yeast type II DNA, topoisomerase reveals a heart-shaped dimeric protein with a large central, hole. It provides a molecular model of the enzyme as an ATP-modulated, clamp with two sets of jaws at opposite ends, connected by multiple, joints. An enzyme with bound DNA can admit a second DNA duplex through one, set of jaws, transport it through the cleaved first duplex, and expel it, through the other set of jaws.
About this Structure
1BGW is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1BGW with [Topoisomerases]. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:8538787
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