2o05

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[[Image:2o05.gif|left|200px]]
[[Image:2o05.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2o05 |SIZE=350|CAPTION= <scene name='initialview01'>2o05</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2o05", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MTA:5&#39;-DEOXY-5&#39;-METHYLTHIOADENOSINE'>MTA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= SRM, SPS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2o05| PDB=2o05 | SCENE= }}
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|RELATEDENTRY=[[2o06|2O06]], [[2o07|2O07]], [[2o0l|2O0L]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o05 OCA], [http://www.ebi.ac.uk/pdbsum/2o05 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o05 RCSB]</span>
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}}
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'''Human spermidine synthase'''
'''Human spermidine synthase'''
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==About this Structure==
==About this Structure==
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2O05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1ZDZ. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O05 OCA].
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2O05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zdz 1zdz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O05 OCA].
==Reference==
==Reference==
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[[Category: Wu, H.]]
[[Category: Wu, H.]]
[[Category: Zeng, H.]]
[[Category: Zeng, H.]]
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[[Category: sgc]]
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[[Category: Sgc]]
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[[Category: spermidine synthase]]
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[[Category: Spermidine synthase]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:08:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:10:55 2008''
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Revision as of 07:08, 4 May 2008

Image:2o05.gif

Template:STRUCTURE 2o05

Human spermidine synthase


Overview

Aminopropyltransferases transfer aminopropyl groups from decarboxylated S-adenosylmethionine to amine acceptors, forming polyamines. Structural and biochemical studies have been carried out with the human spermidine synthase, which is highly specific for putrescine as the amine acceptor, and the Thermotoga maritima spermidine synthase, which prefers putrescine but is more tolerant of other substrates. Comparison of the structures of the human spermidine synthase with both substrates and products with the known structure of T. maritima spermidine synthase complexed to a multisubstrate analogue inhibitor and analysis of the properties of site-directed mutants provide a general mechanistic hypothesis for the aminopropyl transfer reaction. The studies also provide a structural basis for the specificity of the spermidine synthase subclass of the aminopropyltransferase family.

About this Structure

2O05 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1zdz. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of spermidine synthases., Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN, Biochemistry. 2007 Jul 17;46(28):8331-9. Epub 2007 Jun 22. PMID:17585781 Page seeded by OCA on Sun May 4 10:08:29 2008

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OCA

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