2o26

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[[Image:2o26.gif|left|200px]]
[[Image:2o26.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2o26 |SIZE=350|CAPTION= <scene name='initialview01'>2o26</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2o26", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Kitlg, Kitl, Mgf, Sl, Slf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Kit, Sl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_2o26| PDB=2o26 | SCENE= }}
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|RELATEDENTRY=[[2o27|2O27]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o26 OCA], [http://www.ebi.ac.uk/pdbsum/2o26 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o26 RCSB]</span>
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}}
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'''Structure of a class III RTK signaling assembly'''
'''Structure of a class III RTK signaling assembly'''
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[[Category: Liu, H.]]
[[Category: Liu, H.]]
[[Category: 4-helix bundle]]
[[Category: 4-helix bundle]]
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[[Category: class iii]]
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[[Category: Class iii]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: growth factor]]
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[[Category: Growth factor]]
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[[Category: receptor tyrosine kinase]]
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[[Category: Receptor tyrosine kinase]]
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[[Category: receptor/ligand complex]]
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[[Category: Receptor/ligand complex]]
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[[Category: stem cell factor]]
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[[Category: Stem cell factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:13:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:11:38 2008''
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Revision as of 07:13, 4 May 2008

Image:2o26.gif

Template:STRUCTURE 2o26

Structure of a class III RTK signaling assembly


Overview

Stem cell factor (SCF) binds to and activates the KIT receptor, a class III receptor tyrosine kinase (RTK), to stimulate diverse processes including melanogenesis, gametogenesis and hematopoeisis. Dysregulation of KIT activation is associated with many cancers. We report a 2.5 A crystal structure of the functional core of SCF bound to the extracellular ligand-binding domains of KIT. The structure reveals a 'wrapping' SCF-recognition mode by KIT, in which KIT adopts a bent conformation to facilitate each of its first three immunoglobulin (Ig)-like domains to interact with SCF. Three surface epitopes on SCF, an extended loop, the B and C helices, and the N-terminal segment, contact distinct KIT domains, with two of the epitopes undergoing large conformational changes upon receptor binding. The SCF/KIT complex reveals a unique RTK dimerization assembly, and a novel recognition mode between four-helix bundle cytokines and Ig-family receptors. It serves as a framework for understanding the activation mechanisms of class III RTKs.

About this Structure

2O26 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases., Liu H, Chen X, Focia PJ, He X, EMBO J. 2007 Feb 7;26(3):891-901. Epub 2007 Jan 25. PMID:17255936 Page seeded by OCA on Sun May 4 10:13:29 2008

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