2o3m
From Proteopedia
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[[Image:2o3m.gif|left|200px]] | [[Image:2o3m.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_2o3m| PDB=2o3m | SCENE= }} | |
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'''Monomeric G-DNA tetraplex from human C-kit promoter''' | '''Monomeric G-DNA tetraplex from human C-kit promoter''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3M OCA]. | |
==Reference== | ==Reference== | ||
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter., Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ, J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17362008 17362008] | Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter., Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ, J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17362008 17362008] | ||
| - | [[Category: Homo sapiens]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Burge, S.]] | [[Category: Burge, S.]] | ||
[[Category: Kuryavyi, V V.]] | [[Category: Kuryavyi, V V.]] | ||
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[[Category: Patel, D J.]] | [[Category: Patel, D J.]] | ||
[[Category: Phan, A T.]] | [[Category: Phan, A T.]] | ||
| - | [[Category: | + | [[Category: Edgewise]] |
| - | [[Category: | + | [[Category: G-tetrad;parallel g-quadruplex]] |
| - | [[Category: | + | [[Category: Single-residue cha reversal,5-nucleotide snap-back loops;broken strand topolog]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:17:16 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:17, 4 May 2008
Monomeric G-DNA tetraplex from human C-kit promoter
Overview
The c-kit oncogene is an important target in the treatment of gastrointestinal tumors. A potential approach to inhibition of the expression of this gene involves selective stabilization of G-quadruplex structures that may be induced to form in the c-kit promoter region. Here we report on the structure of an unprecedented intramolecular G-quadruplex formed by a G-rich sequence in the c-kit promoter in K+ solution. The structure represents a new folding topology with several unique features. Most strikingly, an isolated guanine is involved in G-tetrad core formation, despite the presence of four three-guanine tracts. There are four loops: two single-residue double-chain-reversal loops, a two-residue loop, and a five-residue stem-loop, which contain base-pairing alignments. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter., Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ, J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16. PMID:17362008 Page seeded by OCA on Sun May 4 10:17:16 2008
