2o4v

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[[Image:2o4v.gif|left|200px]]
[[Image:2o4v.gif|left|200px]]
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{{Structure
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|PDB= 2o4v |SIZE=350|CAPTION= <scene name='initialview01'>2o4v</scene>, resolution 1.94&Aring;
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The line below this paragraph, containing "STRUCTURE_2o4v", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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{{STRUCTURE_2o4v| PDB=2o4v | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o4v OCA], [http://www.ebi.ac.uk/pdbsum/2o4v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o4v RCSB]</span>
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'''An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane'''
'''An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane'''
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[[Category: Moraes, T F.]]
[[Category: Moraes, T F.]]
[[Category: Strynadka, N C.]]
[[Category: Strynadka, N C.]]
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[[Category: channel]]
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[[Category: Channel]]
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[[Category: outer membrane]]
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[[Category: Outer membrane]]
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[[Category: phosphate]]
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[[Category: Phosphate]]
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[[Category: porin]]
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[[Category: Porin]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:19:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:12:45 2008''
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Revision as of 07:19, 4 May 2008

Image:2o4v.gif

Template:STRUCTURE 2o4v

An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane


Overview

The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-A resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from the extracellular surface down through a constriction zone where phosphate is coordinated. Lysine residues coat the inner periplasmic surface, creating an 'electropositive sink' that pulls the phosphates through the eyelet and into the cell.

About this Structure

2O4V is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane., Moraes TF, Bains M, Hancock RE, Strynadka NC, Nat Struct Mol Biol. 2007 Jan;14(1):85-7. Epub 2006 Dec 24. PMID:17187075 Page seeded by OCA on Sun May 4 10:19:41 2008

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