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(New page: 200px<br /> <applet load="1htm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1htm, resolution 2.5Å" /> '''STRUCTURE OF INFLUEN...)
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Revision as of 06:54, 18 November 2007
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STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION
Overview
Low pH induces a conformational change in the influenza virus, haemagglutinin, which then mediates fusion of the viral and host cell, membranes. The three-dimensional structure of a fragment of the, haemagglutinin in this conformation reveals a major refolding of the, secondary and tertiary structure of the molecule. The apolar fusion, peptide moves at least 100 A to one tip of the molecule. At the other end, a helical segment unfolds, a subdomain relocates reversing the chain, direction, and part of the structure becomes disordered.
About this Structure
1HTM is a Protein complex structure of sequences from Uncultured beta proteobacterium umtra-608. The following page contains interesting information on the relation of 1HTM with [Hemagglutinin]. Full crystallographic information is available from OCA.
Reference
Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525
Page seeded by OCA on Sun Nov 18 09:01:31 2007
