2o5n
From Proteopedia
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| - | + | {{STRUCTURE_2o5n| PDB=2o5n | SCENE= }} | |
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'''Crystal structure of a Viral Glycoprotein''' | '''Crystal structure of a Viral Glycoprotein''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O5N OCA]. | |
==Reference== | ==Reference== | ||
Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153., Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, Robinson H, Simic H, Jonjic S, Tiemessen CT, Margulies DH, J Biol Chem. 2007 Nov 30;282(48):35247-58. Epub 2007 Sep 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17897947 17897947] | Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153., Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, Robinson H, Simic H, Jonjic S, Tiemessen CT, Margulies DH, J Biol Chem. 2007 Nov 30;282(48):35247-58. Epub 2007 Sep 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17897947 17897947] | ||
| - | [[Category: Murid herpesvirus 1]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Mans, J.]] | [[Category: Mans, J.]] | ||
[[Category: Margulies, D H.]] | [[Category: Margulies, D H.]] | ||
[[Category: Natarajan, K.]] | [[Category: Natarajan, K.]] | ||
[[Category: Robinson, H.]] | [[Category: Robinson, H.]] | ||
| - | [[Category: | + | [[Category: Alpha-beta protein]] |
| - | [[Category: | + | [[Category: Ig-superfamily]] |
| - | [[Category: | + | [[Category: M145 family]] |
| - | [[Category: | + | [[Category: M153]] |
| - | [[Category: | + | [[Category: Mhc-i-like]] |
| - | [[Category: | + | [[Category: Mhc-iv]] |
| - | [[Category: | + | [[Category: Mouse cytomegalovirus]] |
| - | [[Category: | + | [[Category: Viral protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:21:29 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:21, 4 May 2008
Crystal structure of a Viral Glycoprotein
Overview
Mouse cytomegalovirus (MCMV), a beta-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted major histocompatibility complex, class I (MHC-I) structure. Functions attributed to some family members include down-regulation of host MHC-I (m152) and NKG2D ligands (m145, m152, and m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical, and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require beta2m or peptide and is expressed at the surface of MCMV-infected cells. Its 2.4-A crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended N terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family.
About this Structure
Full crystallographic information is available from OCA.
Reference
Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153., Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, Robinson H, Simic H, Jonjic S, Tiemessen CT, Margulies DH, J Biol Chem. 2007 Nov 30;282(48):35247-58. Epub 2007 Sep 26. PMID:17897947 Page seeded by OCA on Sun May 4 10:21:29 2008
